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Drug Delivery: Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and In Vivo Drug Delivery (Small 24/2013)
Li, Chunxia1; Yang, Dongmei1; Yang, Dongmei Ma, Ping'an1; Chen, Yinyin1; Wu, Yuan1; Hou, Zhiyou1; Dai, Yunlu1; Zhao, Jihong2; Sui, Changping2; Lin, Jun1
2013
Source PublicationSMALL
ISSN1613-6810
Volume9Issue:24Pages:4150-4159
Abstract

Incorporating the agents for magnetic resonance imaging (MRI), optical imaging, and therapy in one nanostructured matrix to construct multifunctional nanomedical platform has attracted great attention for simultaneous diagnostic and therapeutic applications. In this work, a facile methodology is developed to construct a multifunctional anticancer drug nanocarrier by combining the special advantages of upconversion nanoparticles and mesoporous silica. -NaYF4:Yb3+, Er3+@-NaGdF4:Yb3+ is chosen as it can provide the dual modality of upconversion luminescence and MRI. Then mesoporous silica is directly coated onto the upconversion nanoparticles to form discrete, monodisperse, highly uniform, and core-shell structured nanospheres (labeled as UCNPs@mSiO(2)), which are subsequently functionalized with hydrophilic polymer poly(ethylene glycol) (PEG) to improve the colloidal stability and biocompatibility. The obtained multifunctional nanocomposites can be used as an anticancer drug delivery carrier and applied for imaging. The anticancer drug doxorubicin (DOX) is absorbed into UCNPs@mSiO(2)-PEG nanospheres and released in a pH-sensitive pattern. In vitro cell cytotoxicity tests on cancer cells verify that the DOX-loaded UCNPs@mSiO(2)-PEG has comparable cytotoxicity with free DOX at the same concentration of DOX. In addition, the T-1-weighted MRI that measures in aqueous solutions reveals that the contrast brightening increases with the concentration of Gd3+ component. Upconversion luminescence images of UCNPs@mSiO(2)-PEG uptaken by cells show green emission under 980 nm infrared laser excitation. Finally, the nanocomposites show low systematic toxicity and high in vivo antitumor therapy efficacy. These findings highlight the fascinating features of upconversion-mesoporous nanocomposites as multimodality imaging contrast agents and nanocarrier for drug molecules.

KeywordUpconversion Mesoporous Silica Upconversion Cell Imaging Magnetic Resonance Imaging Drug Delivery
DOIhttps://doi.org/10.1002/smll.201301093
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics,
WOS IDWOS:000328453300009
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Cited Times [WOS]:110   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLin, Jun
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
2.Tumor Hosp Jilin Prov, Changchun 130012, Peoples R China
Recommended Citation
GB/T 7714
Li, Chunxia,Yang, Dongmei,Yang, Dongmei Ma, Ping'an,et al. Drug Delivery: Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and In Vivo Drug Delivery (Small 24/2013)[J]. SMALL,2013,9(24):4150-4159.
APA Li, Chunxia.,Yang, Dongmei.,Yang, Dongmei Ma, Ping'an.,Chen, Yinyin.,Wu, Yuan.,...&Lin, Jun.(2013).Drug Delivery: Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and In Vivo Drug Delivery (Small 24/2013).SMALL,9(24),4150-4159.
MLA Li, Chunxia,et al."Drug Delivery: Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and In Vivo Drug Delivery (Small 24/2013)".SMALL 9.24(2013):4150-4159.
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