UM  > 中華醫藥研究院
gamma-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction
Wang, Anqi; Li, Dan; Wang, Shengpeng; Zhou, Fayang; Li, Peng; Wang, Yitao; Lin, Ligen
2018-01
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume40Pages:544-553
Abstract

gamma-Mangostin (gamma-man), an active compound from Garcinia mangostana L., has been discovered as a hepatoprotective agent against oxidative injury. However, the underlying mechanisms remained unclear. The current study showed that gamma-man stimulated the nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2) to enhance antioxidant capacity under oxidative stress, which was partially reversed by treatment of the NRF2 inhibitor, all-trans-retinoic acid. Moreover, gamma-man increased the expression and activity of SIRT1 (silent mating type information regulation 2 homolog 1), which facilitated the deacetylation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha to improve the mitochondrial function in L02 cells. The protective effect of gamma-man was partially blocked by treatment of the SIRT1 inhibitor tenovin-1 or SIRT1 knockdown. In vivo studies showed gamma-man protected mice from carbon tetrachloride-induced acute liver injury, through up-regulation of NRF2 and SIRT1. Thus, gamma-man might be a candidate to protect liver from acute oxidative injury.

KeywordGamma-mangostin Mangosteen Liver Oxidative Injury Nrf2 Sirt1 Pgc-1 Alpha
DOIhttp://doi.org/10.1016/j.jff.2017.11.047
URLView the original
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000428005500058
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese, Medical Sciences, University of Macau, Macao 999078, China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wang, Anqi,Li, Dan,Wang, Shengpeng,et al. gamma-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction[J]. JOURNAL OF FUNCTIONAL FOODS,2018,40:544-553.
APA Wang, Anqi.,Li, Dan.,Wang, Shengpeng.,Zhou, Fayang.,Li, Peng.,...&Lin, Ligen.(2018).gamma-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction.JOURNAL OF FUNCTIONAL FOODS,40,544-553.
MLA Wang, Anqi,et al."gamma-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction".JOURNAL OF FUNCTIONAL FOODS 40(2018):544-553.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Anqi]'s Articles
[Li, Dan]'s Articles
[Wang, Shengpeng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Anqi]'s Articles
[Li, Dan]'s Articles
[Wang, Shengpeng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Anqi]'s Articles
[Li, Dan]'s Articles
[Wang, Shengpeng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Wang-2018--mangostin-a-xanthone-from-mangoste.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.