UM  > 健康科學學院
Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy
Tang, Wei1; Fan, Wenpei1; Wang, Zhantong1; Zhang, Weizhong2; Zhou, Shiyi2; Liu, Yijing1; Yang, Zhen1; Shao, Emily1; Zhang, Guofeng3; Jacobson, Orit1; Shan, Lingling1; Tian, Rui1; Cheng, Siyuan1; Lin, Lisen1; Dai, Yulun1; Shen, Zheyu1; Niu, Gang1; Xie, Jin2; Chen, Xiaoyuan1
2018
Source PublicationACS NANO
ISSN1936-0851
Volume12Issue:12Pages:12269-12283
Abstract

Featured with a large surface area, uniform interpenetrating mesopores, diverse organic framework hybridization, and well-defined surface properties, the hollow mesoporous organosilica nanoparticle (HMON) represents a promising paradigm in drug delivery systems with excellent biocompatibility. However, effective tumor accumulation and precise cancer theranostics of the HMON still remain a challenge. In this study, an "ammonia-assisted hot water etching" method is applied for the successful construction of sub-50 nm thioether/phenylene dual-hybridized HMON with low hemolytic effect. Particularly, the surface modification with Mo(VI)-based polyoxometalate (POM) clusters drives the self-assembly of HMON in the mild acidic tumor microenvironment (TME) to achieve enhanced tumor retention and accumulation. More importantly, the reducibility-activated Mo(VI)-to-Mo(V) conversion within POM not only endows the POM-anchored HMON with outstanding TME-responsive photoacoustic (PA) imaging contrast and photothermal therapy (PTT) performance but also plays an indispensable role in controllably triggering the decomposition of the Mn-2(CO)(10) payload for CO release, which gives rise to remarkable synergistic PTT-enhanced CO gas therapy for complete tumor eradication. By harnessing the unique acidic and redox properties of TME, the judiciously designed smart POM-anchored HMON nanoplatform is expected to act as a "magic bomb" to selectively destroy cancer without damaging normal tissues. This nanoplatform holds significant potential in realizing TME-responsive self-assembly for enhanced tumor accumulation and precise tumor-specific synergistic therapy, which is very promising for clinical translation.

KeywordHollow Mesoporous Organ Osilica Nanoparticle Dual Hybridization Self-assembly Tumor Microenvironment Responsiveness Synergistic Therapy
DOIhttps://doi.org/10.1021/acsnano.8b06058
Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000454567500051
Fulltext Access
Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorFan, Wenpei
Affiliation1.NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA
2.Univ Georgia, Dept Chem, Athens, GA 30602 USA
3.NIBIB, Lab Cellular Imaging & Macromol Biophys, NIH, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Tang, Wei,Fan, Wenpei,Wang, Zhantong,et al. Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy[J]. ACS NANO,2018,12(12):12269-12283.
APA Tang, Wei.,Fan, Wenpei.,Wang, Zhantong.,Zhang, Weizhong.,Zhou, Shiyi.,...&Chen, Xiaoyuan.(2018).Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy.ACS NANO,12(12),12269-12283.
MLA Tang, Wei,et al."Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy".ACS NANO 12.12(2018):12269-12283.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tang, Wei]'s Articles
[Fan, Wenpei]'s Articles
[Wang, Zhantong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tang, Wei]'s Articles
[Fan, Wenpei]'s Articles
[Wang, Zhantong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tang, Wei]'s Articles
[Fan, Wenpei]'s Articles
[Wang, Zhantong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.