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Gadolinium Metallofullerene-Polypyrrole Nanoparticles for Activatable Dual-Modal Imaging-Guided Photothermal Therapy
Wang, Sheng1,2; Zhou, Zijian2; Yu, Guocan2; Lu, Nan2; Liu, Yijing2; Dai, Yunlu2; Fu, Xiao2; Wang, Jing1; Chen, Xiaoyuan2
2018
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:34Pages:28382-28389
Abstract

Accurate diagnosis of tumor is promising to guide photothermal therapy (PTT) for efficacious tumor ablation with minimal damage to healthy tissues. Here, we report an activatable dual-modal imaging agent, which is based on PEGylated-gadolinium metallofullerenepolypyrrole nanoparticle (PEG-GMF-PPy NP) for imaging-guided PTT. A contrast agent (gadolinium metallofullerene, GMF) with excellent magnetic resonance imaging (MM) performance and an ultra-pH-responsive polymer (PEG-PC7A) are successively modified to the surface of photothermal agent (PPy NP). The prepared PEG-GMF-PPy NPs show strong absorption in the near-infrared (NIR) region, so they can be utilized for photoacoustic imaging. Furthermore, in a tumor extracellular environment, the PEG-GMF-PPy NPs can achieve pH-enhanced MRI because of the hydrophobic-to-hydrophilic conversion of the PC7A. Upon accurate diagnosis-guided NIR laser irradiation, excellent tumor ablation effect is achieved. The results suggest that the PEG-GMF-PPy NPs are promising agents for activatable imaging-guided PTT.

KeywordActivatable Contrast Agent Photoacoustic Imaging Photothermal Therapy Gadolinium Metallofullerene Polypyrrole
DOIhttps://doi.org/10.1021/acsami.8b09670
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000443654600015
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWang, Jing
Affiliation1.ourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China
2.Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Wang, Sheng,Zhou, Zijian,Yu, Guocan,et al. Gadolinium Metallofullerene-Polypyrrole Nanoparticles for Activatable Dual-Modal Imaging-Guided Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(34):28382-28389.
APA Wang, Sheng.,Zhou, Zijian.,Yu, Guocan.,Lu, Nan.,Liu, Yijing.,...&Chen, Xiaoyuan.(2018).Gadolinium Metallofullerene-Polypyrrole Nanoparticles for Activatable Dual-Modal Imaging-Guided Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,10(34),28382-28389.
MLA Wang, Sheng,et al."Gadolinium Metallofullerene-Polypyrrole Nanoparticles for Activatable Dual-Modal Imaging-Guided Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 10.34(2018):28382-28389.
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