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Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1
Lee, LTO; Tan-Un, KC; Chow, BKC
2006
Conference Name7th International Symposium on VIP, PACAP and Related Peptides
Source PublicationVIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY
Volume1070
Pages393-398
Conference DateSEP 11-14, 2005
Conference PlaceRouen, FRANCE
Author of SourceVaudry, H; Laburthe, M
PublisherWILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
Abstract

Previously, we found that secretin transcript levels were induced by all-trans retinoic acid (RA) in a neuroblastoma cell model, SH-SY5Y. In this article, this RA-dependent upregulation process was further investigated. In the cyclin-dependent kinase 1 (Cdk1) inhibitor-treated cells, the RA-dependent induction of secretin gene expression was inhibited. Together with our previous works, we propose here that the RA responsiveness of the secretin promotor is mediated by two different pathways. The first pathway is by changing the expression levels of NFI-C and Sp proteins while the second pathway is by modifying the phosphorylation status of both NFI-C and Sp proteins via Cdk1.

KeywordSecretin Promotor Retinoic Acid Cdk1
DOIhttps://doi.org/10.1196/annals.1317.051
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Science & Technology - Other Topics ; Neurosciences & Neurology
WOS SubjectBiochemistry & Molecular Biology ; Multidisciplinary Sciences ; Neurosciences
WOS IDWOS:000240364200055
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionFaculty of Health Sciences
AffiliationUniv Hong Kong, Dept Zool, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Lee, LTO,Tan-Un, KC,Chow, BKC. Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1[C]//Vaudry, H; Laburthe, M:WILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA,2006:393-398.
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