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Multifunctional LaPO4:Ce/Tb@Au mesoporous microspheres: synthesis, luminescence and controllable light triggered drug release
Ruichan Lv; Guixin Yang; Shili Gai; Yunlu Dai; Fei He; Piaoping Yang
2014
Source PublicationRSC Advances
ISSN2046-2069
Volume4Pages:63425-63435
Abstract

Uniform LaPO4:Ce/Tb mesoporous microspheres (MMs) have been successfully prepared by a facile mass production co-precipitation process under mild reaction conditions, without using any surfactant, catalyst or further heating treatment. Then, Au nanoparticles (NPs) were conjugated to polyetherimide (PEI) modified LaPO4:Ce/Tb MMs by electrostatic interactions. It was found that as-prepared LaPO4:Ce/Tb@Au composite consists of well-dispersed mesoporous microspheres with high surface area and narrow pore size distribution. Upon ultraviolet (UV) excitation, LaPO4:Ce/Tb and LaPO4:Ce/Tb@Au MMs exhibit the characteristic green emissions of Tb3+ ions. In addition, the good biocompatibility and sustained doxorubicin (DOX) release properties indicate its promise as a candidate in cancer therapy. In particular, under UV irradiation, a rapid DOX release was achieved due to the photothermal effect of Au NPs derived from the overlap of the green emission of Tb3+ and the surface plasmon resonance (SPR) band of gold NPs at about 530 nm. The MTT assay, cellular uptaken images, the anti-tumor therapy in vivo, and the histology examination results further proved that this novel multifunctional (mesoporous, luminescent, and thermal effect) drug delivery system should be a suitable candidate for cancer therapy carriers.

DOIhttp://doi.org/10.1039/C4RA12942C
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000345701500078
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPiaoping Yang
AffiliationKey Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
Recommended Citation
GB/T 7714
Ruichan Lv,Guixin Yang,Shili Gai,et al. Multifunctional LaPO4:Ce/Tb@Au mesoporous microspheres: synthesis, luminescence and controllable light triggered drug release[J]. RSC Advances,2014,4:63425-63435.
APA Ruichan Lv,Guixin Yang,Shili Gai,Yunlu Dai,Fei He,&Piaoping Yang.(2014).Multifunctional LaPO4:Ce/Tb@Au mesoporous microspheres: synthesis, luminescence and controllable light triggered drug release.RSC Advances,4,63425-63435.
MLA Ruichan Lv,et al."Multifunctional LaPO4:Ce/Tb@Au mesoporous microspheres: synthesis, luminescence and controllable light triggered drug release".RSC Advances 4(2014):63425-63435.
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