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Drug Delivery: Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release
Xiao Zhang1,2; Piaoping Yang2; Yunlu Dai1; Ping'an Ma1; Xuejiao Li1; Ziyong Cheng1; Zhiyao Hou1; Xiaojiao Kang1; Chunxia Li1; Jun Lin1
2013-09-06
Source PublicationAdvanced Functional Materials
ISSN1616-301X
Volume23Issue:33Pages:4062-4062
Abstract

Multifunctional nanocarriers based on the up-conversion luminescent nanoparticles of NaYF4:Yb3+/Er3+ core (UCNPs) and thermo/pH-coupling sensitive polymer poly[(N-isopropylacrylamide)-co-(methacrylic acid)] (P(NIPAm-co-MAA)) gated mesoporous silica shell are reported for cancer theranostics, including fluorescence imaging, and for controlled drug release for therapy. The as-synthesized hybrid nanospheres UCNPs@mSiO(2)-P(NIPAm-co-MAA) show bright green up-conversion fluorescence under 980 nm laser excitation and the thermo/pH-sensitive polymer is active as a valve to moderate the diffusion of the embedded drugs in-and-out of the pore channels of the silica container. The anticancer drug doxorubicin hydrochloride (DOX) can be absorbed into UCNPs@mSiO(2)-P(NIPAm-co-MAA) nanospheres and the composite drug delivery system (DDS) shows a low level of leakage at low temperature/high pH values but significantly enhanced release at higher temperature/lower pH values, exhibiting an apparent thermo/pH controlled on-off drug release pattern. The as-prepared UCNPs@mSiO(2)-P(NIPAm-co-MAA) hybrid nanospheres can be used as bioimaging agents and biomonitors to track the extent of drug release. The reported multifunctional nanocarriers represent a novel and versatile class of platform for simultaneous imaging and stimuli-responsive controlled drug delivery.

KeywordPh/thermo Coupling Sensitivity N‐isopropylacrylamide Drug Delivery Up‐conversion Cell Imaging
DOIhttps://doi.org/10.1002/adfm.201370164
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000327492300003
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Cited Times [WOS]:159   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZiyong Cheng; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
2.Key Laboratory of Superlight Materials and surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
Recommended Citation
GB/T 7714
Xiao Zhang,Piaoping Yang,Yunlu Dai,et al. Drug Delivery: Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release[J]. Advanced Functional Materials,2013,23(33):4062-4062.
APA Xiao Zhang.,Piaoping Yang.,Yunlu Dai.,Ping'an Ma.,Xuejiao Li.,...&Jun Lin.(2013).Drug Delivery: Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release.Advanced Functional Materials,23(33),4062-4062.
MLA Xiao Zhang,et al."Drug Delivery: Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release".Advanced Functional Materials 23.33(2013):4062-4062.
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