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Mesoporous NaYF4:Yb,Er@Au–Pt(IV)-FA nanospheres for dual-modal imaging and synergistic photothermal/chemo-anti-cancer therapy
Ruichan Lv; Guixin Yang; Fei He; Yunlu Dai; Shili Gai; Piaoping Yang
2015
Source PublicationRSC Advances
ISSN2046-2069
Volume5Pages:43391-43401
Abstract

In this report, mesoporous NaYF4:Yb,Er@Au–Pt(IV)-FA up-conversion nanoparticles (UCNPs) have been designed by attaching Au NPs and Pt(IV) pro-drugs on the surface of PEI hydrogel modified mesoporous NaYF4:Yb,Er nanospheres. Finally the molecules modified with folic acid (FA) improve the receptormediated endocytosis. Because of the doped rare earth ions in the host matrix, the as-synthesized platform exhibits excellent up-conversion luminescence (UCL) imaging and computed X-ray tomography (CT) imaging properties. Diverse methods including MTT assay, hemolysis experiments, and live/dead cell analysis were employed to evaluate the biocompatibility and ablation efficacy of the assynthesized platform. It was found that the cytotoxicity of the platform can be tuned by eliminating the axial ligands reductively during intracellular endocytosis. Especially, under 980 nm near-infrared (NIR) irradiation, the platform shows excellent inhibition toward cancer cells due to the synergistic photothermal injury to enzymes and membrane integrity combined with the DNA binding of activated Pt(II) to avoid cell proliferation. The developed nanocomposite may thus be a promising imaging-guided synergistic anti-cancer platform.

DOIhttp://doi.org/10.1039/c5ra05437k
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000354964600043
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Citation statistics
Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorShili Gai; Piaoping Yang
AffiliationKey Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
Recommended Citation
GB/T 7714
Ruichan Lv,Guixin Yang,Fei He,et al. Mesoporous NaYF4:Yb,Er@Au–Pt(IV)-FA nanospheres for dual-modal imaging and synergistic photothermal/chemo-anti-cancer therapy[J]. RSC Advances,2015,5:43391-43401.
APA Ruichan Lv,Guixin Yang,Fei He,Yunlu Dai,Shili Gai,&Piaoping Yang.(2015).Mesoporous NaYF4:Yb,Er@Au–Pt(IV)-FA nanospheres for dual-modal imaging and synergistic photothermal/chemo-anti-cancer therapy.RSC Advances,5,43391-43401.
MLA Ruichan Lv,et al."Mesoporous NaYF4:Yb,Er@Au–Pt(IV)-FA nanospheres for dual-modal imaging and synergistic photothermal/chemo-anti-cancer therapy".RSC Advances 5(2015):43391-43401.
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