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Multifunctional NaYF4: Yb/Er/Gd nanocrystal decorated SiO 2 nanotubes for anti-cancer drug delivery and dual modal imaging
Xuejiao Li1,2; Zhiyao Hou1; Ping’an Ma1; Xiao Zhang1; Chunxia Li1; Ziyong Cheng1; Yunlu Dai1; Jianshe Lian2; Jun Lin1
2013
Source PublicationRSC Advances
ISSN2046-2069
Volume3Pages:8517-8526
Abstract

Silica nanotubes (SNTs) functionalized with magnetic and up-conversion luminescent (UCL) NaYF4:Yb/Er/ Gd nanocrystals (NCs) (denoted as MUCNCs@SNTs) have been prepared by single-nozzle electrospinning based on a phase separation effect without any templates. Monodisperse and hydrophilic cubic a-NaYF4:Yb/Er/Gd NCs decorated with polyethyleneimine (PEI) were fabricated in a facile hydrothermal route. Then, the Gd3+-doped a-NaYF4:Yb/Er NCs were dispersed into the electrospinning precursor solution containing polyvinylpyrrolidone (PVP) and tetraethylorthosilicate (TEOS), followed by the preparation of precursor nanotubes via electrospinning process. Finally, after annealing at 600 uC, pure MUCNCs@SNTs were obtained. The biocompatibility test on L929 fibroblast cells using MTT assay reveals low cytotoxicity of the composites. Doxorubicin hydrochloride (DOX), a typical anti-cancer drug, was introduced into MUCNCs@SNTs to evaluate the loading and sustained release behaviours. The composite carriers provide pH-dependent drug release behaviour owing to abundant Si–OH active bonds of silica and its interactions with DOX. The in vitro cytotoxicity and cell uptake behaviour of the MUCNCs@SNTs for HeLa cells were evaluated. For in vitro magnetic resonance imaging (MRI), the composites show the promising spin lattice relaxation time (T1) weighted effect and could potentially apply as a T1-positive contrast agent. In addition, the composites show near-infrared UC luminescence and were successfully applied in the bioimaging of HeLa cells. Considering the good biocompatibility, high drug releasing content and pH-dependent drug release of the materials, these magnetic and luminescent composite nanotubes have potential applications in drug sustained release and magnetic resonance/UC luminescence modality imaging.

DOIhttp://doi.org/10.1039/c3ra40992a
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000318940800055
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZhiyao Hou; Jun Lin
Affiliation1.State Key laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
2.Key Lab of Automobile Materials, Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun, 130025, PR China
Recommended Citation
GB/T 7714
Xuejiao Li,Zhiyao Hou,Ping’an Ma,et al. Multifunctional NaYF4: Yb/Er/Gd nanocrystal decorated SiO 2 nanotubes for anti-cancer drug delivery and dual modal imaging[J]. RSC Advances,2013,3:8517-8526.
APA Xuejiao Li.,Zhiyao Hou.,Ping’an Ma.,Xiao Zhang.,Chunxia Li.,...&Jun Lin.(2013).Multifunctional NaYF4: Yb/Er/Gd nanocrystal decorated SiO 2 nanotubes for anti-cancer drug delivery and dual modal imaging.RSC Advances,3,8517-8526.
MLA Xuejiao Li,et al."Multifunctional NaYF4: Yb/Er/Gd nanocrystal decorated SiO 2 nanotubes for anti-cancer drug delivery and dual modal imaging".RSC Advances 3(2013):8517-8526.
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