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LaF 3: Ln mesoporous spheres: controllable synthesis, tunable luminescence and application for dual-modal chemo-/photo-thermal therapy
Ruichan Lv; Guixin Yang; Fei He; Yunlu Dai; Shili Gai; Piaoping Yang
2014-12-21
Source PublicationNanoscale
ISSN2040-3364
Volume6Issue:24Pages:14799-809
Abstract

In this report, uniform LaF3:Ln mesoporous spheres have been synthesized by a facile and mild in situ ionexchange method using yolk-like La(OH)3:Ln mesoporous spheres as templates, which were prepared through a self-produced bubble-template route. It was found that the structures of the final LaF3:Ln can simply be tuned by adding a polyetherimide (PEI) reagent. LaF3:Ln hollow mesoporous spheres (HMSs) and LaF3:Ln flower-like mesoporous spheres (FMSs) were obtained when assisted by PEI and in the absence of PEI. The up-conversion (UC) luminescence results reveal that the doping of Nd3+ ions in LaF3: Ln can markedly influence the UC emissions of the products. It is interesting that an obvious thermal effect is achieved due to the energy back-transfer from Tm3+ to Nd3+ ions under 980 nm near-infrared (NIR) irradiation. The LaF3:Yb/Er/Tm/Nd HMSs show good biocompatibility and sustained doxorubicin (DOX) release properties. In particular, upon 980 nm NIR irradiation, the photothermal effect arising from the Nd3+ doping induces a faster DOX release from the drug release system. Moreover, UC luminescence images of LaF3:Yb/Er/Tm/Nd HMSs uptaken by MCF-7 cells exhibit apparent green emission under 980 nm NIR irradiation. Such a multifunctional carrier combining UC luminescence and hyperthermia with the chemotherapeutic drugs should be of high potential for the simultaneous anti-cancer therapy and cell imaging.

DOIhttp://doi.org/10.1039/c4nr04336g
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000345458200029
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorFei He; Piaoping Yang
AffiliationKey Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
Recommended Citation
GB/T 7714
Ruichan Lv,Guixin Yang,Fei He,et al. LaF 3: Ln mesoporous spheres: controllable synthesis, tunable luminescence and application for dual-modal chemo-/photo-thermal therapy[J]. Nanoscale,2014,6(24):14799-809.
APA Ruichan Lv,Guixin Yang,Fei He,Yunlu Dai,Shili Gai,&Piaoping Yang.(2014).LaF 3: Ln mesoporous spheres: controllable synthesis, tunable luminescence and application for dual-modal chemo-/photo-thermal therapy.Nanoscale,6(24),14799-809.
MLA Ruichan Lv,et al."LaF 3: Ln mesoporous spheres: controllable synthesis, tunable luminescence and application for dual-modal chemo-/photo-thermal therapy".Nanoscale 6.24(2014):14799-809.
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