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Lutecium fluoride hollow mesoporous spheres with enhanced up-conversion luminescent bioimaging and light-triggered drug release by gold nanocrystals
Ruichan Lv1; Piaoping Yang1; Yunlu Dai1; Shili Gai1; Fei He1; Jun Lin2
2014
Source PublicationACS Applied Materials & Interfaces
ISSN1944-8244
Volume6Pages:15550−15563
Abstract

Uniform Na5Lu9F32 hollow mesoporous spheres (HMSs) have been successfully prepared by a facile and mild (50 °C for 5 h) coprecipitation process, and Au nanocrystals (NCs) with particle size of about 10 nm were conjugated to poly(ether imide) (PEI) modified HMSs by electrostatic interaction. Compared with Na5Lu9F32:Yb/Er HMSs, the up-conversion (UC) luminescence intensity of Na5Lu9F32:Yb/Er@Au HMSs was much higher under low pump power due to the local field enhancement (LFE) of Au NCs, and there is a surface plasmon resonance (SPR) effect with nonradiative transitions which generates a thermal effect. These two effects have been proved by theoretical discrete-dipole approximation (DDA) simulation. The good biocompatibility of Na5Lu9F32:Yb/Er@Au HMSs indicates them as a promising candidate in the biological field. Particularly, under near-infrared (NIR) laser irradiation, a rapid doxorubicin (DOX) release was achieved due to the thermal effect of Au NCs. In this case, Na5Lu9F32:Yb/Er@Au HMSs exhibit an apparent NIR light-controlled “on/off” drug release pattern. In addition, UC luminescent images uptaken by cells show brighter green and red emission under NIR laser excitation. Therefore, this novel multifunctional (mesoporous, enhanced UC luminescent, and light-triggered drug release) material should be potential as a suitable targeted cancer therapy carrier and bioimaging.

KeywordHollow Mesoporous Up-conversion Luminescence Light-triggered
DOIhttp://dx.doi.org/10.1021/am504347e
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000341544200096
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Cited Times [WOS]:34   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPiaoping Yang; Jun Lin
Affiliation1.Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, Harbin Engineering University, Harbin 150001, P. R. China
2.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130021, P. R. China
Recommended Citation
GB/T 7714
Ruichan Lv,Piaoping Yang,Yunlu Dai,et al. Lutecium fluoride hollow mesoporous spheres with enhanced up-conversion luminescent bioimaging and light-triggered drug release by gold nanocrystals[J]. ACS Applied Materials & Interfaces,2014,6:15550−15563.
APA Ruichan Lv,Piaoping Yang,Yunlu Dai,Shili Gai,Fei He,&Jun Lin.(2014).Lutecium fluoride hollow mesoporous spheres with enhanced up-conversion luminescent bioimaging and light-triggered drug release by gold nanocrystals.ACS Applied Materials & Interfaces,6,15550−15563.
MLA Ruichan Lv,et al."Lutecium fluoride hollow mesoporous spheres with enhanced up-conversion luminescent bioimaging and light-triggered drug release by gold nanocrystals".ACS Applied Materials & Interfaces 6(2014):15550−15563.
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