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Orexins and their receptors from fish to mammals: a comparative approach
Kari K.Y.Wong; Stephanie Y.L.Ng; Leo T.O.Lee; Hans K.H.Ng; Billy K.C.Chow
2011
Source PublicationGENERAL AND COMPARATIVE ENDOCRINOLOGY
ISSN0016-6480
Volume171Issue:2Pages:124-130
Abstract

Although recently discovered, orexins have been rapidly established as important neuropeptides in regulating physiological processes including food intake, sleep/wake cycles and reproduction through binding to two class B G protein-coupled receptors (OX1R and OX2R). To date, a handful of sequences for orexins and their receptors ranging from fish to mammalian species have been identified, allowing a glimpse into their evolution. Structurally, the genetic and molecular organization of the peptides and receptors amongst vertebrates are highly similar, underlining the strong evolutionary pressure that has been exerted to preserve structure and ultimately function. Furthermore, the absence of invertebrate orexin-like sequences suggests early vertebrates as the origin from which orexins evolved. With respect to the receptors, OX2R is probably evolutionary more ancient whilst OX1R is specific to mammalian species and evolved only during this later lineage. In common to all vertebrates studied, the hypothalamus remains to be the key brain region in which orexinergic neurons and fibers are localized in, establishing orexin to be an important player in regulating physiological processes especially those related to food intake and energy metabolism. To allow better understanding of the evolution of orexins and their receptors, this review will provide a comparative approach to their structures and functions in vertebrates.

KeywordOrexin Orexin Receptor Evolution
DOIhttps://doi.org/10.1016/j.ygcen.2011.01.001
Indexed BySCI
Language英语
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000288590100003
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被引频次[WOS]:49   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Corresponding AuthorBilly K.C.Chow
AffiliationSchool of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China
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Kari K.Y.Wong,Stephanie Y.L.Ng,Leo T.O.Lee,et al. Orexins and their receptors from fish to mammals: a comparative approach[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2011,171(2):124-130.
APA Kari K.Y.Wong,Stephanie Y.L.Ng,Leo T.O.Lee,Hans K.H.Ng,&Billy K.C.Chow.(2011).Orexins and their receptors from fish to mammals: a comparative approach.GENERAL AND COMPARATIVE ENDOCRINOLOGY,171(2),124-130.
MLA Kari K.Y.Wong,et al."Orexins and their receptors from fish to mammals: a comparative approach".GENERAL AND COMPARATIVE ENDOCRINOLOGY 171.2(2011):124-130.
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