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PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders
Li Wang1,2; Ruifeng Teng1,3; Lijun Di2; Heather Rogers1; Hong Wu4; Jeffrey B. Kopp5; Constance Tom Noguchi1
2013
Source PublicationDiabetes
ISSN0012-1797
Volume62Issue:12Pages:4122-4131
Abstract

Erythropoietin (EPO) has shown beneficial effects in the regulation of obesity and metabolic syndrome; however, the detailed mechanism is still largely unknown. Here, we created mice with adipocyte-specific deletion of EPO receptor. These mice exhibited obesity and decreased glucose tolerance and insulin sensitivity, especially when fed a high-fat diet. Moreover, EPO increased oxidative metabolism, fatty acid oxidation, and key metabolic genes in adipocytes and in white adipose tissue from diet-induced obese wild-type mice. Increased metabolic activity by EPO is associated with induction of brown fat-like features in white adipocytes, as demonstrated by increases in brown fat gene expression, mitochondrial content, and uncoupled respiration. Peroxisome proliferator-activated receptor (PPAR)α was found to mediate EPO activity because a PPARα antagonist impaired EPO-mediated induction of brown fat-like gene expression and uncoupled respiration. PPARα also cooperates with Sirt1 activated by EPO through modulating the NAD+ level to regulate metabolic activity. PPARα targets, including PPARγ coactivator 1α, uncoupling protein 1, and carnitine palmitoyltransferase 1α, were increased by EPO but impaired by Sirt1 knockdown. Sirt1 knockdown also attenuated adipose response to EPO. Collectively, EPO, as a novel regulator of adipose energy homeostasis via these metabolism coregulators, provides a potential therapeutic strategy to protect against obesity and metabolic disorders.

DOIhttp://dx.doi.org/10.2337/db13-0518
Indexed BySCI
Language英语
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000333738500028
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Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
2.Faculty of Health Sciences, University of Macau, Macau, China
3.Mouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
4.Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California
5.Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Li Wang,Ruifeng Teng,Lijun Di,et al. PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders[J]. Diabetes,2013,62(12):4122-4131.
APA Li Wang.,Ruifeng Teng.,Lijun Di.,Heather Rogers.,Hong Wu.,...&Constance Tom Noguchi.(2013).PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders.Diabetes,62(12),4122-4131.
MLA Li Wang,et al."PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders".Diabetes 62.12(2013):4122-4131.
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