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Multifunctional hollow CaF2:Yb3þ/Er3þ/Mn2þ-poly(2-Aminoethyl methacrylate) microspheres for Pt(IV) pro-drug delivery and tri-modal imaging
Xiaoran Deng1,2; Yunlu Dai1,2; Jianhua Liu3; Ying Zhou4; Ping'an Ma1; Ziyong Cheng1; Yinyin Chen1,2; Kerong Deng1,2; Xuejiao Li1; Zhiyao Hou1; Chunxia Li1; Jun Lin1
2015-05
Source PublicationBiomaterials
ISSN0142-9612
Volume50Pages:154-163
Abstract

Combining the multi-modal medical imaging with cancer therapy in one single system has attracted the great interests for theranostic purpose. In this paper, CaF2:Yb3þ/Er3þ/Mn2þ-poly(2-Aminoethyl methacrylate) (UCHNs-PAMA) hybrid microspheres were successfully fabricated. The synthetic route to the nanocomposite based on a facile hydrothermal method for fabrication of hollow upconversion (UC) nanospheres at first and then post-filling the PAMA interiorly through photo-initiated polymerization. The UCHNs showed orange fluorescence under 980 nm near infrared (NIR) laser excitation, which provided the upconverting luminescence (UCL) imaging modality. Meanwhile, the presence of functional Mn2þ and Yb3þ offered the enhanced T1-weighted magnetic resonance (MR) and computed tomography (CT) imaging, respectively. Thanks to introducing amine groups-containing PAMA inside the hollow nanospheres, the Pt(IV) pro-drug, c,c,t-Pt(NH3)2Cl2(OOCCH2CH2COOH)2 (DSP), can be conveniently bonded on the polymer network to construct a nanoscale anti-cancer drug carrier. The UCHNs-PAMAPt(IV) nanocomposite shows effective inhibition for Hela cell line via MTT assay. In contrast, Pt(IV) pro-drug and UCHNs-PAMA microspheres behave little cytotoxicity to Hela cells. This should be attributed the fact that the anti-cancer ability can be recovered only when Pt(IV) pro-drug was reduced to Pt(II)-drug in cellular environment. Furthermore, the in vivo experiments on small mice also confirm that the hybrid microspheres have relatively low toxic side effects and high tumor inhibition rate. These findings show that the multifunctional hybrid microspheres have potential to be used as UCL/MR/CT trimodal imaging contrast agent and anti-cancer drug carriers.

KeywordCaf2:Yb3þ/er3þ/mn2þ Hollow Microspheres Poly(2-aminoethyl Methacrylate) Drug Delivery Mri/ucl/ct Imaging
DOIhttps://doi.org/10.1016/j.biomaterials.2015.01.040
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000351656000016
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Cited Times [WOS]:43   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZiyong Cheng; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
2.University of Chinese Academy of Sciences, Beijing 100049, China
3.Department of Radiology, The Second Hospital of Jilin University, Changchun 130022, PR China
4.College of Clinical Medicine, Jilin University, Changchun, Jilin 130012, PR China
Recommended Citation
GB/T 7714
Xiaoran Deng,Yunlu Dai,Jianhua Liu,et al. Multifunctional hollow CaF2:Yb3þ/Er3þ/Mn2þ-poly(2-Aminoethyl methacrylate) microspheres for Pt(IV) pro-drug delivery and tri-modal imaging[J]. Biomaterials,2015,50:154-163.
APA Xiaoran Deng.,Yunlu Dai.,Jianhua Liu.,Ying Zhou.,Ping'an Ma.,...&Jun Lin.(2015).Multifunctional hollow CaF2:Yb3þ/Er3þ/Mn2þ-poly(2-Aminoethyl methacrylate) microspheres for Pt(IV) pro-drug delivery and tri-modal imaging.Biomaterials,50,154-163.
MLA Xiaoran Deng,et al."Multifunctional hollow CaF2:Yb3þ/Er3þ/Mn2þ-poly(2-Aminoethyl methacrylate) microspheres for Pt(IV) pro-drug delivery and tri-modal imaging".Biomaterials 50(2015):154-163.
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