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Rattle-type hollow CaWO4:Tb3+@SiO2 nanocapsules as carriers for drug delivery
Xuefeng Zhai1,2; Min Yu1,2; Ziyong Cheng1; Zhiyao Hou1; Ping’an Ma1; Dongmei Yang1; Xiaojiao Kang1; Yunlu Dai1; Dong Wang1; Jun Lin1
2011
Source PublicationDalton transactions
ISSN1477-9226
Volume40Pages:12818–12825
Abstract

Rattle-type hollow nanocapsules are among of the most promising candidates as drug carriers owing to their huge inner space and multifunctional material combination. In this paper, rattle-type hollow CaWO4:Tb3+@SiO2 nanocapsules with a diameter of 100–110 nm and a wall thickness around 10 nm were fabricated. The hollow silica nanospheres were used as nano-reactors and the luminescent core of CaWO4:Tb3+ was post-filled into the nano-reactors by a vacuum nano-casting route combined with a Pechini-type sol–gel method. Subsequently, doxorubicin hydrochloride (DOX), a model of an anti-cancer drug, is loaded into the CaWO4:Tb3+@SiO2 nanocapsules and their cell cytotoxicity, cancer cell uptake and drug release behavior are investigated in vitro. The prepared multifunctional inorganic nanocapsules show a loading capacity for DOX as high as 124 mg g-1 and sustained-release properties. The release profile of the drug from DOX-loaded nanocapsules can last over five days. Besides, the blank CaWO4:Tb3+@SiO2 shows very low cytotoxicity against cancer cell lines (HeLa cell) while the DOX-loaded nanocapsules exhibit relatively high efficiency for killing of HeLa cells. The rapid cancer cell uptake process is observed by confocal laser scanning microscopy. The results indicate that a rattle-type hollow CaWO4:Tb3+@SiO2 nanocapsule has the potential to be used as drug carrier in therapy. Moreover, it is possible to extend the synthetic strategy in this study to other rattle-type multifunctional composites to meet various demands.

DOIhttp://doi.org/10.1039/c1dt10996k
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear
WOS IDWOS:000297560000005
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Cited Times [WOS]:35   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZiyong Cheng; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China
2.Department of Chemistry, Northeast Normal University, Changchun, 130024, P.R. China
Recommended Citation
GB/T 7714
Xuefeng Zhai,Min Yu,Ziyong Cheng,et al. Rattle-type hollow CaWO4:Tb3+@SiO2 nanocapsules as carriers for drug delivery[J]. Dalton transactions,2011,40:12818–12825.
APA Xuefeng Zhai.,Min Yu.,Ziyong Cheng.,Zhiyao Hou.,Ping’an Ma.,...&Jun Lin.(2011).Rattle-type hollow CaWO4:Tb3+@SiO2 nanocapsules as carriers for drug delivery.Dalton transactions,40,12818–12825.
MLA Xuefeng Zhai,et al."Rattle-type hollow CaWO4:Tb3+@SiO2 nanocapsules as carriers for drug delivery".Dalton transactions 40(2011):12818–12825.
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