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Kaempferol and inflammation: From chemistry to medicine
Kasi Pandima Devi1; Dicson Sheeja Malar1; Seyed Fazel Nabavi2; Antoni Sureda3; Jianbo Xiao4,5; Seyed Mohammad Nabavi2; Maria Daglia6
Source PublicationPharmacological Research

Inflammation is an important process of human healing response, wherein the tissues respond to injuries induced by many agents including pathogens. It is characterized by pain, redness and heat in the injured tissues. Chronic inflammation seems to be associated with different types of diseases such as arthritis, allergies, atherosclerosis, and even cancer. In recent years natural product based drugs are considered as the novel therapeutic strategy for prevention and treatment of inflammatory diseases. Among the different types of phyto-constituents present in natural products, flavonoids which occur in many vegetable foods and herbal medicines are considered as the most active constituent, which has the potency to ameliorate inflammation under both in vitro and in vivo conditions. Kaempferol is a natural flavonol present in different plant species, which has been described to possess potent anti-inflammatory properties. Despite the voluminous literature on the anti-inflammatory effects of kaempferol, only very limited review articles has been published on this topic. Hence the present review is aimed to provide a critical overview on the anti-inflammatory effects and the mechanisms of action of kaempferol, based on the current scientific literature. In addition, emphasis is also given on the chemistry, natural sources, bioavailability and toxicity of kaempferol.

KeywordAnti-inflammatory Activity Flavonoids Kaempferol Pro-inflammatory Cytokines
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000361580100001
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Cited Times [WOS]:155   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSeyed Mohammad Nabavi; Maria Daglia
Affiliation1.Department of Biotechnology, Science Campus, Alagappa University, Karaikudi 630 004, Tamil Nadu, India
2.Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, PO Box 19395 5487, Tehran, Iran
3.Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, and CIBERobn (Physiopathology of Obesity and Nutrition), E-07122 Palma de Mallorca, Balearic Islands, Spain
4.State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau
5.Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany
6.Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, 27100 Pavia, Italy
Recommended Citation
GB/T 7714
Kasi Pandima Devi,Dicson Sheeja Malar,Seyed Fazel Nabavi,et al. Kaempferol and inflammation: From chemistry to medicine[J]. Pharmacological Research,2015,99:1-10.
APA Kasi Pandima Devi.,Dicson Sheeja Malar.,Seyed Fazel Nabavi.,Antoni Sureda.,Jianbo Xiao.,...&Maria Daglia.(2015).Kaempferol and inflammation: From chemistry to medicine.Pharmacological Research,99,1-10.
MLA Kasi Pandima Devi,et al."Kaempferol and inflammation: From chemistry to medicine".Pharmacological Research 99(2015):1-10.
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