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Recent advances in drug repositioning for the discovery of new anticancer drugs
Joong Sup Shim1; Jun O. Liu2
2014
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
Volume10Issue:7Pages:654-663
Abstract

Drug repositioning (also referred to as drug repurposing), the process of finding new uses of existing drugs, has been gaining popularity in recent years. The availability of several established clinical drug libraries and rapid advances in disease biology, genomics and bioinformatics has accelerated the pace of both activity-based and in silico drug repositioning. Drug repositioning has attracted particular attention from the communities engaged in anticancer drug discovery due to the combination of great demand for new anticancer drugs and the availability of a wide variety of cell- and target-based screening assays. With the successful clinical introduction of a number of non-cancer drugs for cancer treatment, drug repositioning now became a powerful alternative strategy to discover and develop novel anticancer drug candidates from the existing drug space. In this review, recent successful examples of drug repositioning for anticancer drug discovery from non-cancer drugs will be discussed.

KeywordDrug Repositioning Drug Discovery Cancer Angiogenesis Drug Screening Drug Library
DOIhttps://doi.org/10.7150/ijbs.9224
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000339317100001
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被引频次[WOS]:120   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Corresponding AuthorJoong Sup Shim
Affiliation1.Faculty of Health Sciences, University of Macau, Av. Padre Tomas Pereira, Taipa, Macau SAR, China
2.Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
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Joong Sup Shim,Jun O. Liu. Recent advances in drug repositioning for the discovery of new anticancer drugs[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2014,10(7):654-663.
APA Joong Sup Shim,&Jun O. Liu.(2014).Recent advances in drug repositioning for the discovery of new anticancer drugs.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,10(7),654-663.
MLA Joong Sup Shim,et al."Recent advances in drug repositioning for the discovery of new anticancer drugs".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 10.7(2014):654-663.
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