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Au25 cluster functionalized metal–organic nanostructures for magnetically targeted photodynamic/photothermal therapy triggered by single wavelength 808 nm near-infrared light
Dan Yang; Guixin Yang; Shili Gai; Fei He; Guanghui An; Yunlu Dai; Ruichan Lv; Piaoping Yang
2015
Source PublicationNanoscale
ISSN2040-3364
Volume7Pages:19568–19578
Abstract

Near-infrared (NIR) light-induced cancer therapy has gained considerable interest, but pure inorganic anti-cancer platforms usually suffer from degradation issues. Here, we designed metal–organic frameworks (MOFs) of Fe3O4/ZIF-8-Au25 (IZA) nanospheres through a green and economic procedure. The encapsulated Fe3O4nanocrystals not only produce hyperthemal effects upon NIR light irradiation to effectively kill tumor cells, but also present targeting and MRI imaging capability. More importantly, the attached ultrasmall Au25(SR)18 clusters (about 2.5 nm) produce highly reactive singlet oxygen (1O2) to cause photodynamic effects through direct sensitization under NIR light irradiation. Furthermore, the Au25(SR)18 clusters also give a hand to the hyperthemal effect as photothermal fortifiers. This nanoplatform exhibits high biocompatibility and an enhanced synergistic therapeutic effect superior to any single therapy, as verified by in vitro and in vivo assay. This image-guided therapy based on a metal–organic framework may stimulate interest in developing other kinds of metal–organic materials with multifunctionality for tumor diagnosis and therapy.

DOIhttp://doi.org/10.1039/c5nr06192j
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000365203000027
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Cited Times [WOS]:45   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorShili Gai; Piaoping Yang
AffiliationKey Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin, P. R. China
Recommended Citation
GB/T 7714
Dan Yang,Guixin Yang,Shili Gai,et al. Au25 cluster functionalized metal–organic nanostructures for magnetically targeted photodynamic/photothermal therapy triggered by single wavelength 808 nm near-infrared light[J]. Nanoscale,2015,7:19568–19578.
APA Dan Yang.,Guixin Yang.,Shili Gai.,Fei He.,Guanghui An.,...&Piaoping Yang.(2015).Au25 cluster functionalized metal–organic nanostructures for magnetically targeted photodynamic/photothermal therapy triggered by single wavelength 808 nm near-infrared light.Nanoscale,7,19568–19578.
MLA Dan Yang,et al."Au25 cluster functionalized metal–organic nanostructures for magnetically targeted photodynamic/photothermal therapy triggered by single wavelength 808 nm near-infrared light".Nanoscale 7(2015):19568–19578.
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