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One‐Step Synthesis of Small‐Sized and Water‐Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery
Dr. Dongmei Yang1,2; Dr. Yunlu Dai1,2; Dr. Pingan Ma1; Dr. Xiaojiao Kang1,2; Dr. Ziyong Cheng1; Dr. Chunxia Li1; Prof. Jun Lin1
2013-02-18
Source PublicationChemistry: A European Journal
ISSN0947-6539
Volume19Issue:8Pages:2685-2694
Abstract

Small (2–28 nm) NaREF4 (rare earth (RE)=Nd–Lu, Y) nanoparticles (NPs) were prepared by an oil/water two‐phase approach. Meanwhile, hydrophilic NPs can be obtained through a successful phase‐transition process by introducing the amphiphilic surfactant sodium dodecylsulfate (SDS) into the same reaction system. Hollow‐structured NaREF4 (RE=Y, Yb, Lu) NPs can be fabricated in situ by electron‐beam lithography on solid NPs. The MTT assay indicates that these hydrophilic NPs with hollow structures exhibit good biocompatibility. The as‐prepared hollow‐structured NPs can be used as anti‐cancer drug carriers for drug storage/release investigations. Doxorubicin hydrochloride (DOX) was taken as model drug. The release of DOX from hollow α‐NaLuF4:20 % Yb3+, 2 % Er3+exhibits a pH‐sensitive release patterns. Confocal microscopy observations indicate that the NPs can be taken up by HeLa cells and show obvious anti‐cancer efficacy. Furthermore, α‐NaLuF4:20 % Yb3+, 2 % Er3+ NPs show bright‐red emission under IR excitation, making both the excitation and emission light fall within the “optical window” of biological tissues. The application of α‐NaLuF4:20 % Yb3+, 2 % Er3+ in the luminescence imaging of cells was also investigated, which shows a bright‐red emission without background noise.

KeywordCancer Cell Imaging Drug Delivery Electron‐beam Lithography Nanoparticles
DOIhttps://doi.org/10.1002/chem.201203634
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000314926300017
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被引频次[WOS]:42   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Institute of Chinese Medical Sciences
Corresponding AuthorDr. Chunxia Li; Prof. Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Changchun 130022 (P.R. China), Fax: (+86) 431‐85698041
2.University of the Chinese Academy of Sciences, Beijing 100049 (P.R. China)
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Dr. Dongmei Yang,Dr. Yunlu Dai,Dr. Pingan Ma,et al. One‐Step Synthesis of Small‐Sized and Water‐Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery[J]. Chemistry: A European Journal,2013,19(8):2685-2694.
APA Dr. Dongmei Yang.,Dr. Yunlu Dai.,Dr. Pingan Ma.,Dr. Xiaojiao Kang.,Dr. Ziyong Cheng.,...&Prof. Jun Lin.(2013).One‐Step Synthesis of Small‐Sized and Water‐Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery.Chemistry: A European Journal,19(8),2685-2694.
MLA Dr. Dongmei Yang,et al."One‐Step Synthesis of Small‐Sized and Water‐Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery".Chemistry: A European Journal 19.8(2013):2685-2694.
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