UM  > Faculty of Health Sciences
One‐Step Synthesis of Small‐Sized and Water‐Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery
Dr. Dongmei Yang1,2; Dr. Yunlu Dai1,2; Dr. Pingan Ma1; Dr. Xiaojiao Kang1,2; Dr. Ziyong Cheng1; Dr. Chunxia Li1; Prof. Jun Lin1
2013-02-18
Source PublicationChemistry: A European Journal
ISSN0947-6539
Volume19Issue:8Pages:2685-2694
Abstract

Small (2–28 nm) NaREF4 (rare earth (RE)=Nd–Lu, Y) nanoparticles (NPs) were prepared by an oil/water two‐phase approach. Meanwhile, hydrophilic NPs can be obtained through a successful phase‐transition process by introducing the amphiphilic surfactant sodium dodecylsulfate (SDS) into the same reaction system. Hollow‐structured NaREF4 (RE=Y, Yb, Lu) NPs can be fabricated in situ by electron‐beam lithography on solid NPs. The MTT assay indicates that these hydrophilic NPs with hollow structures exhibit good biocompatibility. The as‐prepared hollow‐structured NPs can be used as anti‐cancer drug carriers for drug storage/release investigations. Doxorubicin hydrochloride (DOX) was taken as model drug. The release of DOX from hollow α‐NaLuF4:20 % Yb3+, 2 % Er3+exhibits a pH‐sensitive release patterns. Confocal microscopy observations indicate that the NPs can be taken up by HeLa cells and show obvious anti‐cancer efficacy. Furthermore, α‐NaLuF4:20 % Yb3+, 2 % Er3+ NPs show bright‐red emission under IR excitation, making both the excitation and emission light fall within the “optical window” of biological tissues. The application of α‐NaLuF4:20 % Yb3+, 2 % Er3+ in the luminescence imaging of cells was also investigated, which shows a bright‐red emission without background noise.

KeywordCancer Cell Imaging Drug Delivery Electron‐beam Lithography Nanoparticles
DOIhttps://doi.org/10.1002/chem.201203634
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000314926300017
Fulltext Access
Citation statistics
Cited Times [WOS]:43   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Institute of Chinese Medical Sciences
Corresponding AuthorDr. Chunxia Li; Prof. Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Changchun 130022 (P.R. China), Fax: (+86) 431‐85698041
2.University of the Chinese Academy of Sciences, Beijing 100049 (P.R. China)
Recommended Citation
GB/T 7714
Dr. Dongmei Yang,Dr. Yunlu Dai,Dr. Pingan Ma,et al. One‐Step Synthesis of Small‐Sized and Water‐Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery[J]. Chemistry: A European Journal,2013,19(8):2685-2694.
APA Dr. Dongmei Yang.,Dr. Yunlu Dai.,Dr. Pingan Ma.,Dr. Xiaojiao Kang.,Dr. Ziyong Cheng.,...&Prof. Jun Lin.(2013).One‐Step Synthesis of Small‐Sized and Water‐Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery.Chemistry: A European Journal,19(8),2685-2694.
MLA Dr. Dongmei Yang,et al."One‐Step Synthesis of Small‐Sized and Water‐Soluble NaREF4 Upconversion Nanoparticles for In Vitro Cell Imaging and Drug Delivery".Chemistry: A European Journal 19.8(2013):2685-2694.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Dr. Dongmei Yang]'s Articles
[Dr. Yunlu Dai]'s Articles
[Dr. Pingan Ma]'s Articles
Baidu academic
Similar articles in Baidu academic
[Dr. Dongmei Yang]'s Articles
[Dr. Yunlu Dai]'s Articles
[Dr. Pingan Ma]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Dr. Dongmei Yang]'s Articles
[Dr. Yunlu Dai]'s Articles
[Dr. Pingan Ma]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.