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Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence
Lei Chen1; Hui Teng1; Zhen Jia1; Maurizio Battino2; Anca Miron3; Zhiling Yu4; Hui Cao1,4; Jianbo Xiao4
2017-07-06
Source PublicationCritical reviews in food science and nutrition
ISSN1040-8398
Pages1-17
Abstract

Dietary flavonoids, which occurin manyplant foods, are considered as the most activeconstituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist’s literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-kB, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs.
 

KeywordFlavonoids Inflammation Intracellular Signaling Pathways Structure-activity Relationship
DOIhttps://doi.org/10.1080/10408398.2017.1345853
Language英语
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhiling Yu; Jianbo Xiao
Affiliation1.College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China
2.Center for Nutrition & Health, Universidad Europea del Atlantico, Santander, Spain and Dept. of Clinical Sciences, Universitr Nutrition & Health, Universidad Europea
3.Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, Romania
4.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade, Taipa, Macau
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Lei Chen,Hui Teng,Zhen Jia,et al. Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence[J]. Critical reviews in food science and nutrition,2017:1-17.
APA Lei Chen.,Hui Teng.,Zhen Jia.,Maurizio Battino.,Anca Miron.,...&Jianbo Xiao.(2017).Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence.Critical reviews in food science and nutrition,1-17.
MLA Lei Chen,et al."Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence".Critical reviews in food science and nutrition (2017):1-17.
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