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Reducible Disulfide-Based Non-Viral Gene Delivery Systems
Ouyang, Defang1,2; Shah, Neha1; Zhang, Hong2; Smith, Sean C.2; Parekh, Harendra S.1
2009
Source PublicationMini-Reviews in Medicinal Chemistry
ISSN1389-5575
Volume9Issue:10Pages:1242-1250
Abstract

The design and synthesis of safe efficient non-viral vectors for gene delivery has attracted significant attention in recent years due primarily to the severe side-effect profile reported with the use of their viral counterparts. Previous experiments have revealed that the strong interaction between the carriers and nucleic acid may well hinder the release of the gene from the complex in the cytosol adversely affecting transfection efficiency. However, incorporating reducible disulfide bonds within the delivery systems themselves which are then cleaved in the glutathione-rich intracellular environment may help in solving this puzzle. This review focuses on recent development of these reducible carriers. The biological rationale and approaches to the synthesis of reducible vectors are discussed in detail. The in vitro and in vivo evaluations of reducible carriers are also summarized and it is evident that they offer a promising approach in non-viral gene delivery system design.

KeywordDisulphide Bond Reducible Vector Non-viral Vector Gene Delivery
DOIhttp://www.doi.org/10.2174/138955709789055225
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000271619500009
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia
2.Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Computat Mol Sci, Brisbane, Qld 4072, Australia
Recommended Citation
GB/T 7714
Ouyang, Defang,Shah, Neha,Zhang, Hong,et al. Reducible Disulfide-Based Non-Viral Gene Delivery Systems[J]. Mini-Reviews in Medicinal Chemistry,2009,9(10):1242-1250.
APA Ouyang, Defang,Shah, Neha,Zhang, Hong,Smith, Sean C.,&Parekh, Harendra S..(2009).Reducible Disulfide-Based Non-Viral Gene Delivery Systems.Mini-Reviews in Medicinal Chemistry,9(10),1242-1250.
MLA Ouyang, Defang,et al."Reducible Disulfide-Based Non-Viral Gene Delivery Systems".Mini-Reviews in Medicinal Chemistry 9.10(2009):1242-1250.
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