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Electrospun Upconversion Composite Fibers as Dual Drugs Delivery System with Individual Release Properties
Zhiyao Hou1; Xuejiao Li1,2; Chunxia Li1; Yunlu Dai1; Ping’an Ma1; Xiao Zhang1; Xiaojiao Kang1; Xiaojiao Kang1; Jun Lin1
2013-07-30
Source PublicationLangmuir
ISSN0743-7463
Volume29Issue:30Pages:9473-9482
Abstract

Novel multifunctional poly(ε-caprolactone)- gelatin encapsulating upconversion core/shell silica nanoparticles (NPs) composite fibers as dual drugs delivery system (DDDS), with indomethacin (IMC) and doxorubicin (DOX) releasing in individual release properties, have been designed and fabricated via electrospinning process. Uniform and monodisperse upconversion (UC) luminescent NaYF4:Yb3+, Er3+ nanocrystals (UCNCs) were encapsulated with mesoporous silica shells, resulting in the formation of core/shell structured NaYF4:Yb3+, Er3+@mSiO2 (UCNCs@mSiO2) NPs, which can be performed as DOX delivery carriers. These UCNCs@mSiO2 NPs loading DOX then were dispersed into the mixture of poly(ε-caprolactone) (PCL) and gelatin-based electrospinning solution containing IMC, followed by the preparation of dual drug-loaded composite fibers (DDDS) via electrospinning method. The drugs release profiles of the DDDS were measured, and the results indicated that the IMC and DOX released from the electrospun composite fibers showed distinct properties. The IMC in the composite fibers presented a fast release manner, while DOX showed a sustained release behavior. Moreover, the UC luminescent intensity ratios of 2 H11/2/4 S3/2−4 I15/2 to 4 F9/2−4 I15/2 from Er3+ vary with the amounts of DOX in the system, and thus drug release can be tracked and monitored by the luminescence resonance energy transfer (LRET) mechanism.

DOIhttp://dx.doi.org/10.1021/la402080y
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS IDWOS:000322695000021
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Cited Times [WOS]:64   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorChunxia Li; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China
2.Key Lab of Automobile Materials, Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130025, People’s Republic of China
Recommended Citation
GB/T 7714
Zhiyao Hou,Xuejiao Li,Chunxia Li,et al. Electrospun Upconversion Composite Fibers as Dual Drugs Delivery System with Individual Release Properties[J]. Langmuir,2013,29(30):9473-9482.
APA Zhiyao Hou.,Xuejiao Li.,Chunxia Li.,Yunlu Dai.,Ping’an Ma.,...&Jun Lin.(2013).Electrospun Upconversion Composite Fibers as Dual Drugs Delivery System with Individual Release Properties.Langmuir,29(30),9473-9482.
MLA Zhiyao Hou,et al."Electrospun Upconversion Composite Fibers as Dual Drugs Delivery System with Individual Release Properties".Langmuir 29.30(2013):9473-9482.
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