UM  > 健康科學學院
A facile fabrication of upconversion luminescent and mesoporous core–shell structured β-NaYF4:Yb3+, Er3+@mSiO2 nanocomposite spheres for anti-cancer drug delivery and cell imaging
Chunxia Li; Zhiyao Hou; Yunlu Dai; Dongmei Yang; Ziyong Cheng; Ping'an Ma; Jun Lin
2013
Source PublicationBiomaterials Science
ISSN2047-4830
Volume1Issue:2Pages:213–223
Abstract

Upconversion luminescent β-NaYF4:Yb3+, Er3+ nanoparticles (UCNPs) were encapsulated with uniform mesoporous silica shells, which were further modified with poly(ethylene glycol) (PEG) and cancer-targeting ligand folic acid (FA), resulting in the formation of water-dispersible and biologically functionalized core–shell structured UCNPs@mSiO2 nanoparticles with an overall average size of around 80 nm. The obtained multifunctional nanocomposite spheres can be performed as an anti-cancer drug delivery carrier and applied for cell imaging. It is found that anti-cancer drug doxorubicin hydrochloride (DOX) can be absorbed into UCNPs@mSiO2-PEG/FA nanospheres and released in a pH-sensitive pattern. In vitro cell cytotoxicity tests on cancer cells verified that DOX-loaded UCNPs@mSiO2-PEG/FA nanospheres exhibited greater cytotoxicity with respect to free DOX and DOX-loaded UCNPs@mSiO2-PEG at the same concentrations, owing to the increase of cell uptake of anti-cancer drug delivery vehicles mediated by the FA receptor. Moreover, the upconversion luminescence image of UCNPs@mSiO2-PEG/FA taken up by cells shows green emission under 980 nm infrared laser excitation, making the UCNPs@mSiO2-PEG/FA nanocomposite spheres promising candidates as bioimaging agents. These findings highlight the promise of the highly versatile multifunctional nanoparticles for simultaneous imaging and therapeutic applications.

DOIhttp://doi.org/10.1039/c2bm00087c
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000330133100009
Fulltext Access
Citation statistics
Cited Times [WOS]:79   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPing'an Ma
AffiliationState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 13002, P. R. China
Recommended Citation
GB/T 7714
Chunxia Li,Zhiyao Hou,Yunlu Dai,et al. A facile fabrication of upconversion luminescent and mesoporous core–shell structured β-NaYF4:Yb3+, Er3+@mSiO2 nanocomposite spheres for anti-cancer drug delivery and cell imaging[J]. Biomaterials Science,2013,1(2):213–223.
APA Chunxia Li.,Zhiyao Hou.,Yunlu Dai.,Dongmei Yang.,Ziyong Cheng.,...&Jun Lin.(2013).A facile fabrication of upconversion luminescent and mesoporous core–shell structured β-NaYF4:Yb3+, Er3+@mSiO2 nanocomposite spheres for anti-cancer drug delivery and cell imaging.Biomaterials Science,1(2),213–223.
MLA Chunxia Li,et al."A facile fabrication of upconversion luminescent and mesoporous core–shell structured β-NaYF4:Yb3+, Er3+@mSiO2 nanocomposite spheres for anti-cancer drug delivery and cell imaging".Biomaterials Science 1.2(2013):213–223.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chunxia Li]'s Articles
[Zhiyao Hou]'s Articles
[Yunlu Dai]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chunxia Li]'s Articles
[Zhiyao Hou]'s Articles
[Yunlu Dai]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chunxia Li]'s Articles
[Zhiyao Hou]'s Articles
[Yunlu Dai]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.