UM  > Faculty of Health Sciences
Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI
Ziyong Cheng1; Yunlu Dai2; Xiaojiao Kang2; Chunxia Li1; Shanshan Huang1; Hongzhou Lian1; Zhiyao Hou1; Pingan Ma1; Jun Lin1
2014-08
Source PublicationBiomaterials
ISSN0142-9612
Volume35Issue:24Pages:6359-6368
Abstract

A facile method for transferring hydrophobic iron oxide nanoparticles (IONPs) from chloroform to aqueous solution via encapsulation of FITC-modified gelatin based on the hydrophobicehydrophobic interaction is described in this report. Due to the existence of large amount of active groups such as amine groups in gelatin, the fluorescent labeling molecules of fluorescein isothiocyanate (FITC) and platinum (IV) prodrug functionalized with carboxylic groups can be conveniently conjugated on the IONPs. The nanoparticles carrying Pt(IV) prodrug exhibit good anticancer activities when the Pt(IV) complexes are reduced to Pt(II) in the intracellular environment, while the pure Pt(IV) prodrug only presents lower cytotoxicity on cancer cells. Meanwhile, fluorescence of FITC on the surface of nanoparticles was completely quenched due to the possible Förster Resonance Energy Transfer (FRET) mechanism and showed a fluorescence recovery after gelatin release and detachment from IONPs. Therefore FITC as a fluorescence probe can be used for identification, tracking and monitoring the drug release. In addition, adding pancreatic enzyme can effectively promote the gelatin release from IONPs owing to the degradation of gelatin. Noticeable darkening in magnetic resonance image (MRI) was observed at the tumor site after in situ injection of nanoparticles, indicating the IONPs-enhanced T2- weighted imaging. Our results suggest that the gelatin encapsulated Fe3O4 nanoparticles have potential applications in multi-functional drug delivery system for disease therapy, MR imaging and fluorescence sensor.

KeywordIron Oxide Gelatin Encapsulation Magnetic Resonance Imaging Platinum (Iv) Prodrug Fluorescence Quenching
DOIhttps://doi.org/10.1016/j.biomaterials.2014.04.029
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000338804500021
Fulltext Access
Citation statistics
Cited Times [WOS]:72   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorJun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
2.University of the Chinese Academy of Sciences, Beijing 100049, PR China
Recommended Citation
GB/T 7714
Ziyong Cheng,Yunlu Dai,Xiaojiao Kang,et al. Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI[J]. Biomaterials,2014,35(24):6359-6368.
APA Ziyong Cheng.,Yunlu Dai.,Xiaojiao Kang.,Chunxia Li.,Shanshan Huang.,...&Jun Lin.(2014).Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI.Biomaterials,35(24),6359-6368.
MLA Ziyong Cheng,et al."Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI".Biomaterials 35.24(2014):6359-6368.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ziyong Cheng]'s Articles
[Yunlu Dai]'s Articles
[Xiaojiao Kang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ziyong Cheng]'s Articles
[Yunlu Dai]'s Articles
[Xiaojiao Kang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ziyong Cheng]'s Articles
[Yunlu Dai]'s Articles
[Xiaojiao Kang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.