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Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI
Ziyong Cheng1; Yunlu Dai2; Xiaojiao Kang2; Chunxia Li1; Shanshan Huang1; Hongzhou Lian1; Zhiyao Hou1; Pingan Ma1; Jun Lin1
2014-08
Source PublicationBiomaterials
ISSN0142-9612
Volume35Issue:24Pages:6359-6368
Abstract

A facile method for transferring hydrophobic iron oxide nanoparticles (IONPs) from chloroform to aqueous solution via encapsulation of FITC-modified gelatin based on the hydrophobicehydrophobic interaction is described in this report. Due to the existence of large amount of active groups such as amine groups in gelatin, the fluorescent labeling molecules of fluorescein isothiocyanate (FITC) and platinum (IV) prodrug functionalized with carboxylic groups can be conveniently conjugated on the IONPs. The nanoparticles carrying Pt(IV) prodrug exhibit good anticancer activities when the Pt(IV) complexes are reduced to Pt(II) in the intracellular environment, while the pure Pt(IV) prodrug only presents lower cytotoxicity on cancer cells. Meanwhile, fluorescence of FITC on the surface of nanoparticles was completely quenched due to the possible Förster Resonance Energy Transfer (FRET) mechanism and showed a fluorescence recovery after gelatin release and detachment from IONPs. Therefore FITC as a fluorescence probe can be used for identification, tracking and monitoring the drug release. In addition, adding pancreatic enzyme can effectively promote the gelatin release from IONPs owing to the degradation of gelatin. Noticeable darkening in magnetic resonance image (MRI) was observed at the tumor site after in situ injection of nanoparticles, indicating the IONPs-enhanced T2- weighted imaging. Our results suggest that the gelatin encapsulated Fe3O4 nanoparticles have potential applications in multi-functional drug delivery system for disease therapy, MR imaging and fluorescence sensor.

KeywordIron Oxide Gelatin Encapsulation Magnetic Resonance Imaging Platinum (Iv) Prodrug Fluorescence Quenching
DOIhttps://doi.org/10.1016/j.biomaterials.2014.04.029
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000338804500021
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被引频次[WOS]:64   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Corresponding AuthorJun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
2.University of the Chinese Academy of Sciences, Beijing 100049, PR China
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Ziyong Cheng,Yunlu Dai,Xiaojiao Kang,et al. Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI[J]. Biomaterials,2014,35(24):6359-6368.
APA Ziyong Cheng.,Yunlu Dai.,Xiaojiao Kang.,Chunxia Li.,Shanshan Huang.,...&Jun Lin.(2014).Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI.Biomaterials,35(24),6359-6368.
MLA Ziyong Cheng,et al."Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI".Biomaterials 35.24(2014):6359-6368.
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