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Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers
Li Gan1; Jing Wang1,2; Min Jiang1,2; Hanah Bartlett3; Defang Ouyang3; Frank Eperjesi3; Jianping Liu2; Yong Gan1
2013-03
Source PublicationDrug discovery today
ISSN1359-6446
Volume18Issue:5-6Pages:290-297
Other Abstract

Ocular barriers and the poor water solubility of drug candidates present a number of problems for the development of ocular drug delivery systems. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the bioavailability of ophthalmic formulations. A number of these formulations have been found to be clinically active and several others are currently undergoing clinical trials. In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented. Many systems, including emulsions, liposomes, cubosomes, niosomes and other lipid-based nanocarriers, are reviewed.

DOIhttps://doi.org/10.1016/j.drudis.2012.10.005
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000316427000010
PublisherELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
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Cited Times [WOS]:97   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China
2.School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China
3.Ophthalmic Research Group, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
Recommended Citation
GB/T 7714
Li Gan,Jing Wang,Min Jiang,et al. Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers[J]. Drug discovery today,2013,18(5-6):290-297.
APA Li Gan.,Jing Wang.,Min Jiang.,Hanah Bartlett.,Defang Ouyang.,...&Yong Gan.(2013).Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers.Drug discovery today,18(5-6),290-297.
MLA Li Gan,et al."Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers".Drug discovery today 18.5-6(2013):290-297.
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