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Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release
Xiaojiao Kang1,2; Dongmei Yang1,2; Yunlu Dai1,2; Mengmeng Shang1,2; Ziyong Cheng1; Xiao Zhang1; Hongzhou Lian1; Ping’an Ma1; Jun Lin1
2013-01-07
Source PublicationNanoscale
ISSN2040-3364
Volume5Issue:1Pages:253–261
Abstract

In this study, multifunctional poly(acrylic acid) modified lanthanide-doped GdVO4 nanocomposites [PAA@GdVO4: Ln3+ (Ln ¼ Yb/Er, Yb/Ho, Yb/Tm)] were constructed by filling PAA hydrogel into GdVO4 hollow spheres via photoinduced polymerization. The up-conversion (UC) emission colors (green, red and blue) can be tuned by changing the codopant compositions in the matrices. The composites have potential applications as bio-probes for cell imaging. Meanwhile, the hybrid spheres can act as T1 contrast agents for magnetic resonance imaging (MRI) owing to the existence of Gd3+ ions on the surface of composites. Due to the nature of PAA, DOX-loaded PAA@GdVO4:Yb3+/Er3+ system exhibits pH-dependent drug releasing kinetics. A lower pH offers a faster drug release rate. Such character makes the loaded DOX easily released at cancer cells. The cell uptake process of drug-loaded composites was observed by using confocal laser scanning microscopy (CLSM). The results indicate the potential application of the multifunctional composites as theragnostics (effective bimodal imaging probes and pH-responsive drug carriers).

DOIhttp://doi.org/10.1039/c2nr33130f
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000313347200032
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Cited Times [WOS]:73   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPing’an Ma; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
2.University of the Chinese Academy of Sciences, Beijing, 100049, P. R. China
Recommended Citation
GB/T 7714
Xiaojiao Kang,Dongmei Yang,Yunlu Dai,et al. Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release[J]. Nanoscale,2013,5(1):253–261.
APA Xiaojiao Kang.,Dongmei Yang.,Yunlu Dai.,Mengmeng Shang.,Ziyong Cheng.,...&Jun Lin.(2013).Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release.Nanoscale,5(1),253–261.
MLA Xiaojiao Kang,et al."Poly(acrylic acid) modified lanthanide-doped GdVO4 hollow spheres for up-conversion cell imaging, MRI and pH-dependent drug release".Nanoscale 5.1(2013):253–261.
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