UM  > 健康科學學院
Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anticancer Drug Carrier and MRI Contrast Agent
Xiaojiao Kang1,2; Dongmei Yang1,2; Ping’an Ma1; Yunlu Dai1,2; Mengmeng Shang1,2; Dongling Geng1,2; Ziyong Cheng1; Jun Lin1
2013-01-03
Source PublicationLangmuir
ISSN0743-7463
Volume29Pages:1286−1294
Abstract

Hollow and porous structured GdVO4:Dy3+ spheres were fabricated via a facile self-sacrificing templated method. The large cavity allows them to be used as potential hosts for therapeutic drugs, and the porous feature of the shell allows guest molecules to easily pass through the void space and surrounding environment. The samples show strong yellow-green emission of Dy3+ (485 nm, 4 F9/2 → 6 H15/2; 575 nm, 4 F9/2 → 6 H13/2) under UV excitation. The emission intensity of GdVO4:Dy3+ was weakened after encapsulation of anticancer drug (doxorubicin hydrochloride, DOX) and gradually restored with the cumulative released time of DOX. These hollow spheres were nontoxic to HeLa cells, while DOX-loaded samples led to apparent cytotoxicity as a result of the sustained release of DOX. ICP measurement indicates that free toxic Gd ions can hardly dissolate from the matrix. The endocytosis process of DOX-loaded hollow spheres is observed using confocal laser scanning microscopy (CLSM). Furthermore, GdVO4:Dy3+ hollow spheres can be used for T1-weighted magnetic resonance (MR) imaging. These results implicate that the luminescent GdVO4:Dy3+ spheres with hollow and porous structure are promising platforms for drug storage/release and MR imaging

DOIhttp://dx.doi.org/10.1021/la304551y
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS IDWOS:000314391300038
Fulltext Access
Citation statistics
Cited Times [WOS]:63   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZiyong Cheng; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China
2.University of the Chinese Academy of Sciences, Beijing 100049, People’s Republic of China
Recommended Citation
GB/T 7714
Xiaojiao Kang,Dongmei Yang,Ping’an Ma,et al. Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anticancer Drug Carrier and MRI Contrast Agent[J]. Langmuir,2013,29:1286−1294.
APA Xiaojiao Kang.,Dongmei Yang.,Ping’an Ma.,Yunlu Dai.,Mengmeng Shang.,...&Jun Lin.(2013).Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anticancer Drug Carrier and MRI Contrast Agent.Langmuir,29,1286−1294.
MLA Xiaojiao Kang,et al."Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anticancer Drug Carrier and MRI Contrast Agent".Langmuir 29(2013):1286−1294.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xiaojiao Kang]'s Articles
[Dongmei Yang]'s Articles
[Ping’an Ma]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xiaojiao Kang]'s Articles
[Dongmei Yang]'s Articles
[Ping’an Ma]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xiaojiao Kang]'s Articles
[Dongmei Yang]'s Articles
[Ping’an Ma]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.