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Doxorubicin conjugated NaYF4:Yb3+/Tm3+ nanoparticles for therapy and sensing of drug delivery by luminescence resonance energy transfer
YunluDai1,2; Dongmei Yang1,2; Ping’an Ma1; Xiaojiao Kang1,2; Xiao Zhang1; Chunxia Li1; Zhiyao Hou1; Ziyong Cheng1; Jun Lin1
2012
Source PublicationBiomaterials
ISSN0142-9612
Volume33Issue:33Pages:8704-8713
Abstract

In this study, we report an anticancer drug delivery system based on doxorubicin (DOX)-conjugated NaYF4:Yb3þ/Tm3þ nanoparticles. The as-synthesized nanoparticles consist of uniform spherical nanoparticles with an average diameter of 25 nm. The drug delivery system demonstrates the ability to release DOX by cleavage of the hydrazone bond in mildly acidic environments. The spectra overlap between emission of donor NaYF4:Yb3þ/Tm3þ nanoparticles at 452 nm (1 D2/3 F4) and 477 nm ( 1 G4/3 H6) and the broad absorbance of acceptor DOX centered at around 480 nm enables energy transfer to occur between the nanoparticles and DOX. The quenching and recovery of the up-conversion luminescence of NaYF4:Yb3þ/Tm3þ by DOX due to luminescence resonance energy transfer (LRET) mechanism are applied as optical probe to confirm the DOX conjunction and monitor the release of DOX. The DOX-conjugated NaYF4:Yb3þ/Tm3þ nanoparticles exhibit an obvious cytotoxic effect on SKOV3 ovarian cancer cells via MTT assay. Meanwhile, the endocytosis process of DOX-conjugated NaYF4:Yb3þ/ Tm3þ nanoparticles by SKVO3 cells was demonstrated through confocal laser scanning microscopy (CLSM), flow cytometry and ICP-OES. Such drug delivery system, which combines pH-triggered drugrelease and up-converting nanoparticles-based LRET property, has excellent potential applications in cancer therapy and smart imaging.

KeywordPh-responsive Drug Release Luminescence Resonance Energy Transfer Up-conversion Nanopatricles Doxorubicin
DOIhttps://doi.org/10.1016/j.biomaterials.2012.08.029
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000310401000048
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被引频次[WOS]:74   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Corresponding AuthorZiyong Cheng; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
2.Graduate University of the Chinese Academy of Sciences, Beijing 100049, China
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GB/T 7714
YunluDai,Dongmei Yang,Ping’an Ma,et al. Doxorubicin conjugated NaYF4:Yb3+/Tm3+ nanoparticles for therapy and sensing of drug delivery by luminescence resonance energy transfer[J]. Biomaterials,2012,33(33):8704-8713.
APA YunluDai.,Dongmei Yang.,Ping’an Ma.,Xiaojiao Kang.,Xiao Zhang.,...&Jun Lin.(2012).Doxorubicin conjugated NaYF4:Yb3+/Tm3+ nanoparticles for therapy and sensing of drug delivery by luminescence resonance energy transfer.Biomaterials,33(33),8704-8713.
MLA YunluDai,et al."Doxorubicin conjugated NaYF4:Yb3+/Tm3+ nanoparticles for therapy and sensing of drug delivery by luminescence resonance energy transfer".Biomaterials 33.33(2012):8704-8713.
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