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Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment
Yunlu Dai1,2; Can Xu2; Xiaolian Sun1; Xiaoyuan Chen2
2017-06-21
Source PublicationChemical Society Reviews
ISSN0306-0012
Volume46Issue:12Pages:3830--3852
Abstract

Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH. There are many types of cells, including tumour cells, macrophages, immune and fibroblast cells, fed by defective blood vessels in the solid tumour. Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with a special emphasis on tumour microenvironment stimuli-responsive ones. Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted. Future challenges and opportunities of design consideration are also discussed in detail. We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinic.

DOIhttp://doi.org/10.1039/c6cs00592f
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Chemistry
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Multidisciplinary
WOS IDWOS:000403555500010
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Cited Times [WOS]:178   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorXiaolian Sun; Xiaoyuan Chen
Affiliation1.Centre for Molecular Imaging and Translational Medicine, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiang’an South Road, Xiamen 361102, China
2.Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA.
Recommended Citation
GB/T 7714
Yunlu Dai,Can Xu,Xiaolian Sun,et al. Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment[J]. Chemical Society Reviews,2017,46(12):3830--3852.
APA Yunlu Dai,Can Xu,Xiaolian Sun,&Xiaoyuan Chen.(2017).Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment.Chemical Society Reviews,46(12),3830--3852.
MLA Yunlu Dai,et al."Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment".Chemical Society Reviews 46.12(2017):3830--3852.
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