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Efficacy of classic Chinese medicine formula Ditan Decoction for Alzheimer's disease
CHUA Ka-kit; CHEN Lei-lei; LIU Liang-feng; Durairajan Siva Sundara Kumar; LU Jia-hong; LI Min
2014-04-22
Source PublicationChinese Journal of Integrative Medicine
ISSN1672-0415
Pages1-5
Abstract

Objective: Determine the effi cacy and safety of classic Chinese medicine formula Ditan Decoction (涤痰汤, DTD) for the treatment of Alzheimer's disease (AD) by reviewing the methods and results reported in laboratory and clinical studies in order to suggest strategies for developing more effective drugs for AD. Methods: Embase (OVID) and China Journal Net (CJN) were searched for articles published between 1947 to November 2011 and 1915 to November 2011 respectively. Articles that fulfilled the inclusion criteria and did not meet the exclusion criteria were collected and compared in terms of research method, interventions and outcomes. Results: No articles were found in Embase (OVID); 8 were found in CJN (4 laboratory studies; 4 clinical studies). The laboratory studies showed that memory impairment of AD mice models were signifi cantly improved by DTD. The clinical studies showed that Chinese medicine which include DTD, can also relieve the memory impairment of AD patients, however, the data about the exactly effectiveness of DTD was inconclusive. Conclusions: All the clinical trials have not been fully designed yet. The evidences for recommending DTD in clinical practice were methodologically fl awed. Rigid randomization in controlled clinical trials of DTD with adequate blinding and rating methods are highly recommended.

KeywordAlzheimer's Disease Chinese Medicine Ditan Decoction
DOIhttps://doi.org/10.1007/s11655-014-1346-x
Language英语
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLI Min
AffiliationSchool of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina
Recommended Citation
GB/T 7714
CHUA Ka-kit,CHEN Lei-lei,LIU Liang-feng,et al. Efficacy of classic Chinese medicine formula Ditan Decoction for Alzheimer's disease[J]. Chinese Journal of Integrative Medicine,2014:1-5.
APA CHUA Ka-kit,CHEN Lei-lei,LIU Liang-feng,Durairajan Siva Sundara Kumar,LU Jia-hong,&LI Min.(2014).Efficacy of classic Chinese medicine formula Ditan Decoction for Alzheimer's disease.Chinese Journal of Integrative Medicine,1-5.
MLA CHUA Ka-kit,et al."Efficacy of classic Chinese medicine formula Ditan Decoction for Alzheimer's disease".Chinese Journal of Integrative Medicine (2014):1-5.
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