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Generation of bispecific antibodies by Fc heterodimerization and their application
Chen, ZZ1; Wang, LP2; Xu, TS2,3; Wang, QF2; Kang, LS4; Zhao, Q1
2016
Source PublicationCURRENT PHARMACEUTICAL BIOTECHNOLOGY
ISSN1389-2010
Volume17Issue:15Pages:1324-1332
Abstract

Bispecific antibodies with binding specificities for two different antigens have prompted a lot of interest into their development and application. Currently, more than ten bispecific antibodies have been clinically validated for the treatment of various diseases, including cancers and inflammatory diseases. Intensive studies in antibody engineering drive the generation of different bispecific antibody formats that differ in size and shape. However, the most prominent formats, such as IgG-single-chain (sc) Fv or dual-variable domain (DVD) IgG, deviating from the natural IgG structure, may lead to manufacturing difficulties or increase the potential risk of immunogenicity. Thus, the recent efforts focus on the development of bispecific antibodies by Fc heterodimerization that maintain the native structure of the antibody IgG molecule. This review summarizes the various techniques and methods to generate bispecific antibody molecules with Fc heterodimerization, and discusses perspectives of their application.

KeywordBispecific Antibody Fc Heterodimerization Quadroma Knobs-into-holes Strand-exchange Engineered Domain
DOIhttps://doi.org/10.2174/1389201017666161018150553
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS IDWOS:000390351700004
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZhao, Q
Affiliation1.Univ Macau, Fac Hlth Sci, Macau, Peoples R China
2.Jilin Univ, Sch Life Sci, Changchun, Jilin, Peoples R China
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Guangzhou, Guangdong, Peoples R China
4.Novo Nordisk Res Ctr China, Beijing, Peoples R China
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Chen, ZZ,Wang, LP,Xu, TS,et al. Generation of bispecific antibodies by Fc heterodimerization and their application[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2016,17(15):1324-1332.
APA Chen, ZZ,Wang, LP,Xu, TS,Wang, QF,Kang, LS,&Zhao, Q.(2016).Generation of bispecific antibodies by Fc heterodimerization and their application.CURRENT PHARMACEUTICAL BIOTECHNOLOGY,17(15),1324-1332.
MLA Chen, ZZ,et al."Generation of bispecific antibodies by Fc heterodimerization and their application".CURRENT PHARMACEUTICAL BIOTECHNOLOGY 17.15(2016):1324-1332.
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