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A New Single 808 nm NIR Light‐Induced Imaging‐Guided Multifunctional Cancer Therapy Platform
Fei He1; Guixin Yang1; Piaoping Yang1; Yuxiu Yu1; Ruichan Lv1; Chunxia Li2; Yunlu Dai1; Shili Gai1; Jun Lin2
2015-05-22
Source PublicationAdvanced Functional Materials
ISSN1616-301X
Volume25Pages:3966–3976
Abstract

The NIR light‐induced imaging‐guided cancer therapy is a promising route in the targeting cancer therapy field. However, up to now, the existing single‐modality light‐induced imaging effects are not enough to meet the higher diagnosis requirement. Thus, the multifunctional cancer therapy platform with multimode light‐induced imaging effects is highly desirable. In this work, captopril stabilized‐Au nanoclusters Au25(Capt)18−(Au25) are assembled into the mesoporous silica shell coating outside of Nd3+‐sensitized upconversion nanoparticles (UCNPs) for the first time. The newly formed Au25 shell exhibits considerable photothermal effects, bringing about the photothermal imaging and photoacoustic imaging properties, which couple with the upconversion luminescence imaging. More importantly, the three light‐induced imaging effects can be simultaneously achieved by exciting with a single NIR light (808 nm), which is also the triggering factor for the photothermal and photodynamic cancer therapy. Besides, the nanoparticles can also present the magnetic resonance and computer tomography imaging effects due to the Gd3+ and Yb3+ ions in the UCNPs. Furthermore, due to the photodynamic and the photothermal effects, the nanoparticles possess efficient in vivo tumor growth inhibition under the single irradiation of 808 nm light. The multifunctional cancer therapy platform with multimode imaging effects realizes a true sense of light‐induced imaging‐guided cancer therapy.

DOIhttps://doi.org/10.1002/adfm.201500464
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000357268900019
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Cited Times [WOS]:115   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPiaoping Yang; Jun Lin
Affiliation1.Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, , Harbin, 150001 P. R. China
2.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, , Changchun, 130021 P. R. China
Recommended Citation
GB/T 7714
Fei He,Guixin Yang,Piaoping Yang,et al. A New Single 808 nm NIR Light‐Induced Imaging‐Guided Multifunctional Cancer Therapy Platform[J]. Advanced Functional Materials,2015,25:3966–3976.
APA Fei He.,Guixin Yang.,Piaoping Yang.,Yuxiu Yu.,Ruichan Lv.,...&Jun Lin.(2015).A New Single 808 nm NIR Light‐Induced Imaging‐Guided Multifunctional Cancer Therapy Platform.Advanced Functional Materials,25,3966–3976.
MLA Fei He,et al."A New Single 808 nm NIR Light‐Induced Imaging‐Guided Multifunctional Cancer Therapy Platform".Advanced Functional Materials 25(2015):3966–3976.
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