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Regulatory Roles of Alu Transcript on Gene Expression Regulation
Li Zhang1; Ju-Gao Chen2; Qi Zhao1
2015
Source PublicationEXPERIMENTAL CELL RESEARCH
ISSN0014-4827
Volume338Issue:1Pages:113-118
Abstract

Alu element is the most successful transposon and it maintains a high level of content in primate genome. However, despite the fact that the expression level of independent Alu element is rather low under common condition, an increasing number of the observations for the Alu transcripts in cells and tissues have been reported recently. Alu transcripts play key roles in the network of gene expression regulation. The main functions of Alu transcript focus on gene regulation both at transcriptional and post-transcriptional levels. This review summarizes major functions of Alu transcripts on gene expression and highlights molecular mechanisms dependent on conserved sequence or secondary structure in order to unravel a relative ubiquitous way that Alu transcript uses to affect the whole genome.

KeywordAlu Element Microrna Noncoding Rna Double Stranded Rna Gene Expression Iralus
DOIhttps://doi.org/10.1016/j.yexcr.2015.07.019
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000362999100014
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Laboratory of Fully Human Antibody Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China
2.Department of Oncology, The Second Clinical Medical college (Shenzhen People׳s Hospital), Jinan University, Shenzhen, Guangdong, China
Recommended Citation
GB/T 7714
Li Zhang,Ju-Gao Chen,Qi Zhao. Regulatory Roles of Alu Transcript on Gene Expression Regulation[J]. EXPERIMENTAL CELL RESEARCH,2015,338(1):113-118.
APA Li Zhang,Ju-Gao Chen,&Qi Zhao.(2015).Regulatory Roles of Alu Transcript on Gene Expression Regulation.EXPERIMENTAL CELL RESEARCH,338(1),113-118.
MLA Li Zhang,et al."Regulatory Roles of Alu Transcript on Gene Expression Regulation".EXPERIMENTAL CELL RESEARCH 338.1(2015):113-118.
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