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Ultra-small BaGdF5-based upconversion nanoparticles as drug carriers and multimodal imaging probes
Dongmei Yang1; Yunlu Dai1; Jianhua Liu2; Ying Zhou3; Yinyin Chen1; Chunxia Li1; Ping’an Ma1; Jun Lin1
2014
Source PublicationBiomaterials
ISSN0142-9612
Volume35Pages:2011-2023
Abstract

A new type of drug-delivery system (DDS) was constructed, in which the anti-cancer drug doxorubicin (DOX) was conjugated to the ultra-small sized (sub-10 nm) BaGdF5:Yb3þ/Tm3þ based upconversion nanoparticles (UCNPs). This multifunctional DDS simultaneously possesses drug delivery and optical/ magnetic/X-ray computed tomography imaging capabilities. The DOX can be selectively released by cleavage of hydrazone bonds in acidic environment, which shows a pH-triggered drug release behavior. The MTT assay shows these DOX-conjugated UCNPs exhibit obvious cytotoxic effect on HeLa cells. Moreover, to improve the upconversion luminescence intensity, coreeshell structured UCNPs were constructed. The in vitro upconversion luminescence images of these UCNPs uptaken by HeLa cells show bright emission with high contrast. In addition, these UCNPs were further explored for T1-weighted magnetic resonance (MR) and X-ray computed tomography (CT) imaging in vitro. Long-term in vivo toxicity studies indicated that mice intravenously injected with 10 mg/kg of UCNPs survived for 40 days without any apparent adverse effects to their health. The results indicate that this multifunctional drugdelivery system with optimized size, excellent optical/MR/CT trimodal imaging capabilities, and pHtriggered drug release property is expected to be a promising platform for simultaneous cancer therapy and bioimaging.

KeywordBagdf5 Upconversion Nanoparticle Drug Delivery Multimodal Imaging
DOIhttps://doi.org/10.1016/j.biomaterials.2013.11.018
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000331018700023
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被引频次[WOS]:116   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Faculty of Health Sciences
Corresponding AuthorPing’an Ma; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
2.Department of Radiology, The Second Hospital of Jilin University, Changchun 130022, PR China
3.College of Clinical Medicine, Jilin University, Changchun, Jilin 130012, PR China
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Dongmei Yang,Yunlu Dai,Jianhua Liu,et al. Ultra-small BaGdF5-based upconversion nanoparticles as drug carriers and multimodal imaging probes[J]. Biomaterials,2014,35:2011-2023.
APA Dongmei Yang.,Yunlu Dai.,Jianhua Liu.,Ying Zhou.,Yinyin Chen.,...&Jun Lin.(2014).Ultra-small BaGdF5-based upconversion nanoparticles as drug carriers and multimodal imaging probes.Biomaterials,35,2011-2023.
MLA Dongmei Yang,et al."Ultra-small BaGdF5-based upconversion nanoparticles as drug carriers and multimodal imaging probes".Biomaterials 35(2014):2011-2023.
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