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Up-Conversion Luminescent and Porous NaYF 4 :Yb 3 + , Er 3 + @SiO 2 Nanocomposite Fibers for Anti-Cancer Drug Delivery and Cell Imaging
Zhiyao Hou1,2; Chunxia Li1; Ping'an Ma1; Ziyong Cheng1; Xuejiao Li1; Xiao Zhang1; Yunlu Dai1; Dongmei Yang1; Hongzhou Lian1; Jun Lin1
2012-07-10
Source PublicationAdvanced Functional Materials
ISSN1616-301X
Volume22Issue:13Pages:2713-2722
Abstract

Up‐conversion (UC) luminescent and porous NaYF4:Yb3+, Er3+@SiO2 nanocomposite fibers are prepared by electrospinning process. The biocompatibility test on L929 fibrolast cells reveals low cytotoxicity of the fibers. The obtained fibers can be used as anti‐cancer drug delivery host carriers for investigation of the drug storage/release properties. Doxorubicin hydrochloride (DOX), a typical anticancer drug, is introduced into NaYF4:Yb3+, Er3+@SiO2 nanocomposite fibers (denoted as DOX‐NaYF4:Yb3+, Er3+@SiO2). The release properties of the drug carrier system are examined and the in vitro cytotoxicity and cell uptake behavior of these NaYF4:Yb3+, Er3+@SiO2 for HeLa cells are evaluated. The release of DOX from NaYF4:Yb3+, Er3+@SiO2 exhibits sustained, pH‐sensitive release patterns and the DOX‐NaYF4:Yb3+, Er3+@SiO2 show similar cytotoxicity as the free DOX on HeLa cells. Confocal microscopy observations show that the composites can be effectively taken up by HeLa cells. Furthermore, the fibers show near‐infrared UC luminescence and are successfully applied in bioimaging of HeLa cells. The results indicate the promise of using NaYF4:Yb3+, Er3+@SiO2 nanocomposite fibers as multi‐functional drug carriers for drug delivery and cell imaging.

DOIhttps://doi.org/10.1002/adfm.201200082
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000305945000007
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Cited Times [WOS]:116   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPing'an Ma; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
2.Key Laboratory of Superlight Materials and surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
Recommended Citation
GB/T 7714
Zhiyao Hou,Chunxia Li,Ping'an Ma,et al. Up-Conversion Luminescent and Porous NaYF 4 :Yb 3 + , Er 3 + @SiO 2 Nanocomposite Fibers for Anti-Cancer Drug Delivery and Cell Imaging[J]. Advanced Functional Materials,2012,22(13):2713-2722.
APA Zhiyao Hou.,Chunxia Li.,Ping'an Ma.,Ziyong Cheng.,Xuejiao Li.,...&Jun Lin.(2012).Up-Conversion Luminescent and Porous NaYF 4 :Yb 3 + , Er 3 + @SiO 2 Nanocomposite Fibers for Anti-Cancer Drug Delivery and Cell Imaging.Advanced Functional Materials,22(13),2713-2722.
MLA Zhiyao Hou,et al."Up-Conversion Luminescent and Porous NaYF 4 :Yb 3 + , Er 3 + @SiO 2 Nanocomposite Fibers for Anti-Cancer Drug Delivery and Cell Imaging".Advanced Functional Materials 22.13(2012):2713-2722.
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