UM  > Faculty of Health Sciences
Location of sentinel lymph node in gastric cancer: a modified, painless and noninvasive approach
Xin-hui Su1; Qiang Chen2; Long Sun1; Hua Wu1; Wei-Ming Pan1; Gui-bing Chen1; Zuo-Ming Luo1; Wei Wang3
2010
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume22Issue:1Pages:55-61
Abstract

Objective: The presence of lymph node metastases is an important factor in the prognosis of gastric cancer patient. Therefore, the precise identification of sentinel lymph nodes (SLN) in these patients is critical. In this work, we investigated the feasibility and preciseness by injection of 99mTc-sulfur colloid (SC) 2 hours before operation after general anesthesia, instead of one day before surgery.
Methods: Thirty-one patients of gastric cancer diagnosed as T1−T3 were enrolled in this study. During operation, a SLN was defined as those containing 10 times more radioactivity than surrounding tissue with a hand-held gamma
probe and removed. All the patients underwent radical gastrectomy with extended lymphadenectomy. All resected nodes were examined postoperatively by routine H&E stain and those negative SLNs were examined with further cytokeratin immunohistochemistical staining.
Results: The incidence of metastasis was significantly higher in SLNs than in non-SLNs (x2=67.48, P<0.001). The overall sensitivity, specificity and accuracy of the SLN status in the diagnosis of the lymph node status of the patient were 86.36%, 100% and 96.77%, respectively. The positive predictive value and negative predictive value of SLN biopsy were 100%, and 75.0%, respectively. SLNs were used to diagnose the lymph node status with 100% accuracy in the T1 group. In the T2 and T3 groups, the sensitivity, specificity, and diagnostic accuracy were 92.3%, 100%, and 94.44%, 60.0%, 100%, and 66.66%, respectively. Most of the SLNs were located in the #1, #2, #3, #4, #5, and #6, except in 3 patients (9.68%).With cytokeratin immunohistochemical staining, lymphatic pathologic staging in l patient was upstaged.
Conclusion: SLN biopsy with the above approach is a feasible and accurate diagnostic procedure for detecting lymph node metastasis in patients with gastric cancer, which is painless, noninvasive, easily accepted by patients and suitable for extensive clinical applications.

KeywordGastric Cancer Sentinel Lymph Node Location Radiocolloid Injection Time
DOIhttps://doi.org/10.1007/s11670-010-0055-2
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000274464600009
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWei Wang
Affiliation1.Department of Nuclear Medicine, the First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, China
2.School of Life Sciences, Xiamen University, Xiamen, China
3.Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fujian, China
Recommended Citation
GB/T 7714
Xin-hui Su,Qiang Chen,Long Sun,et al. Location of sentinel lymph node in gastric cancer: a modified, painless and noninvasive approach[J]. CHINESE JOURNAL OF CANCER RESEARCH,2010,22(1):55-61.
APA Xin-hui Su.,Qiang Chen.,Long Sun.,Hua Wu.,Wei-Ming Pan.,...&Wei Wang.(2010).Location of sentinel lymph node in gastric cancer: a modified, painless and noninvasive approach.CHINESE JOURNAL OF CANCER RESEARCH,22(1),55-61.
MLA Xin-hui Su,et al."Location of sentinel lymph node in gastric cancer: a modified, painless and noninvasive approach".CHINESE JOURNAL OF CANCER RESEARCH 22.1(2010):55-61.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xin-hui Su]'s Articles
[Qiang Chen]'s Articles
[Long Sun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xin-hui Su]'s Articles
[Qiang Chen]'s Articles
[Long Sun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xin-hui Su]'s Articles
[Qiang Chen]'s Articles
[Long Sun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.