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Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery
Dongmei Yang1,2; Xiaojiao Kang1,2; Ping’an Ma1; Yunlu Dai1,2; Zhiyao Hou1; Ziyong Cheng1; Chunxia Li1; Jun Lin1
2013-02
Source PublicationBiomaterials
ISSN0142-9612
Volume34Issue:5Pages:1601-1612
Abstract

Uniform a-NaYF4:Yb3þ, Er3þ nanospheres (w130 nm) with mesoporous shell and hollow interior structure were synthesized by using Y(OH)CO3:Yb3þ, Er3þ nanospheres (NPs) as sacrificial templates via a surface-protected “etching” and hydrothermal ion-exchange process. In this process, polyethylenimine (PEI) ligands played a key role in formation of the hollow structured a-NaYF4 nanospheres, i.e., they can effectively protect the surface of the Y(OH)CO3 from rapid dissolution by Hþ. Moreover, folic acid (FA), a commonly used cancer-targeting agent was conjugated on the surface of NPs based on the presence of free amine groups. The as-prepared FA-modified hollow NPs can be performed as anti-cancer drug carriers for the investigation of drug storage/release properties, which exhibit greater cytotoxicity than DOX-loaded a-NaYF4 NPs due to the specific cell uptake by HeLa cells via FA receptor-mediate endocytosis. Furthermore, upconversion (UC) luminescence images of FA-modified a-NaYF4:Yb3þ, Er3þ NPs uptaken by cells shows bright green emission without background noise under 980 nm infrared laser excitation. Thus, these multifunctional nanospheres combining UC luminescent property and hollow and mesoporous structure have potential for simultaneous targeted anti-cancer drug delivery and cell imaging.

KeywordHollow Structure Nayf4 Upconversion Drug Delivery Cell Imaging
DOIhttps://doi.org/10.1016/j.biomaterials.2012.11.004
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000313929400016
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Cited Times [WOS]:164   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorChunxia Li; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China
2.University of the Chinese Academy of Sciences, Beijing 100049, PR China
Recommended Citation
GB/T 7714
Dongmei Yang,Xiaojiao Kang,Ping’an Ma,et al. Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery[J]. Biomaterials,2013,34(5):1601-1612.
APA Dongmei Yang.,Xiaojiao Kang.,Ping’an Ma.,Yunlu Dai.,Zhiyao Hou.,...&Jun Lin.(2013).Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery.Biomaterials,34(5),1601-1612.
MLA Dongmei Yang,et al."Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery".Biomaterials 34.5(2013):1601-1612.
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