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A Yolk-like Multifunctional Platform for Multimodal Imaging and Synergistic Therapy Triggered by a Single Near-Infrared Light
Ruichan Lv1; Piaoping Yang1; Fei He1; Shili Gai1; Chunxia Li2; Yunlu Dai1; Guixin Yang1; Jun Lin2
2015
Source PublicationACS Nano
ISSN1936-0851
Volume9Issue:2Pages:1630–1647
Abstract

To integrate photodynamic therapy (PDT) with photothermal therapy (PTT) and chemotherapy for enhanced antitumor efficiency, we developed a mild and rational route to synthesize novel multifunctional GdOF:Ln@SiO2 (Ln = 10%Yb/1% Er/4%Mn) mesoporous capsules using strong up-conversion luminescent (UCL) GdOF:Ln as cores and mesoporous silica layer as shells, followed by modification with varied functional groups onto the framework. It was found that due to the codoped Yb/Er/Mn in GdOF, the markedly enhanced red emission can efficiently transfer energy to the conjugated PDT agent (ZnPc) which produces high singlet oxygen, and the incorporated carbon dots outside the shell can generate obvious thermal effect under 980 nm laser irradiation and also prevent the premature leaking of ZnPc. Simultaneously, the as-produced thermal effect can obviously enhance the doxorubicin (DOX) release, which greatly improves the chemotherapy, resulting in a synergistic therapeutic effect. The system exhibits drastically enhanced therapeutic efficiency against tumor growth, as demonstrated both in vitro and in vivo. Especially, the doped rare earth ions in the host endow the material with excellent UCL imaging, magnetic resonance imaging (MRI), and computed tomography (CT) imaging properties, thus realizing the target of multimodal imaging guided multiple therapies.

KeywordPhotodynamic Therapy Photothermal Therapy Bioimaging Up-conversion Gdof
DOIhttp://doi.org/10.1021/nn5063613
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000349940500059
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPiaoping Yang; Jun Lin
Affiliation1.Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
2.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Harbin 130021, P. R. China
Recommended Citation
GB/T 7714
Ruichan Lv,Piaoping Yang,Fei He,et al. A Yolk-like Multifunctional Platform for Multimodal Imaging and Synergistic Therapy Triggered by a Single Near-Infrared Light[J]. ACS Nano,2015,9(2):1630–1647.
APA Ruichan Lv.,Piaoping Yang.,Fei He.,Shili Gai.,Chunxia Li.,...&Jun Lin.(2015).A Yolk-like Multifunctional Platform for Multimodal Imaging and Synergistic Therapy Triggered by a Single Near-Infrared Light.ACS Nano,9(2),1630–1647.
MLA Ruichan Lv,et al."A Yolk-like Multifunctional Platform for Multimodal Imaging and Synergistic Therapy Triggered by a Single Near-Infrared Light".ACS Nano 9.2(2015):1630–1647.
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