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A TPA-caged precursor of (imino)coumarin for “turn-on” fluorogenic detection of Cu+
Zhangjun Hu1; Jiwen Hu1,2; Hui Wang3; Qiong Zhang1; Meng Zhao3; Caroline Brommesson1; Yupeng Tian3; Hongwen Gao2; Xuanjun Zhang1,4; Uvdal, Kajsa1

We strategize to utilize the precursors of (imino) coumarin fluorophores to deliver novel reactive Cu+ probes, where tris[(2-pyridyl)-methyl] amine (TPA) works as a reactive receptor towards Cu+. To verify this strategy, CP1, a representative probe and relevant sensing behaviors towards Cu+ are presented here. CP1 features good solubility and fast response for monitoring labile copper in aqueous solution and live cells. The sensing mechanism of CP1 is determined by HPLC titration and mass spectrometric analysis. The probe CP1 exhibits a 60-fold fluorescence enhancement and a detection limitation of10.8 nM upon the detection of Cu+. CP1 is further applied for imaging labile copper in live cells. This work provides a starting point for future development of Cu+ probes, based on in situ formation of(imino) coumarin scaffolds, as well as their further investigations of copper signaling and biological events. (C) 2016 Elsevier B.V. All rights reserved.

KeywordFluorogenic Probe Copper Ions (Imino)Coumarin Reaction-based Fluorescence
Indexed BySCI
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000380849400021
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Faculty of Health Sciences
Affiliation1.Division of Molecular Surface Physics & Nanoscience, Department of Physics, Chemistry and Biology, Linköping University, Linköping 58183, Sweden
2.State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China
3.Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Department of Chemistry, Anhui University, Hefei 230039, PR China
4.Faculty of Health Sciences, University of Macau, Taipa, Macau, PR China
Recommended Citation
GB/T 7714
Zhangjun Hu,Jiwen Hu,Hui Wang,et al. A TPA-caged precursor of (imino)coumarin for “turn-on” fluorogenic detection of Cu+[J]. ANALYTICA CHIMICA ACTA,2016,933:189-195.
APA Zhangjun Hu.,Jiwen Hu.,Hui Wang.,Qiong Zhang.,Meng Zhao.,...&Uvdal, Kajsa.(2016).A TPA-caged precursor of (imino)coumarin for “turn-on” fluorogenic detection of Cu+.ANALYTICA CHIMICA ACTA,933,189-195.
MLA Zhangjun Hu,et al."A TPA-caged precursor of (imino)coumarin for “turn-on” fluorogenic detection of Cu+".ANALYTICA CHIMICA ACTA 933(2016):189-195.
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