UM  > 健康科學學院
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
Shunyou Wang1,2; Jing Gao1,2; Qunying Lei1,2; Nora Rozengurt3; Colin Pritchard4; Jing Jiao1,2; George V. Thomas3; Gang Li1,2; Pradip Roy-Burman5; Peter S. Nelson4; Xin Liu2,3; Hong Wu1,2
2003
Source PublicationCANCER CELL
ISSN1535-6108
Volume4Issue:3Pages:209-221
Other Abstract

The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those “signature” genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.
 

DOIhttps://doi.org/10.1016/S1535-6108(03)00215-0
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000185595000008
Fulltext Access
Citation statistics
Cited Times [WOS]:709   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorHong Wu
Affiliation1.Howard Hughes Medical Institute
2.Department of Molecular and Medical Pharmacology University of California Los Angeles School of Medicine, Los Angeles, California 90095
3.Department of Pathology and Laboratory Medicine University of California Los Angeles School of Medicine, Los Angeles, California 90095
4.Division of Human Biology Mailstop D4-100, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, Washington 98109
5.Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, California 90033
Recommended Citation
GB/T 7714
Shunyou Wang,Jing Gao,Qunying Lei,et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer[J]. CANCER CELL,2003,4(3):209-221.
APA Shunyou Wang.,Jing Gao.,Qunying Lei.,Nora Rozengurt.,Colin Pritchard.,...&Hong Wu.(2003).Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.CANCER CELL,4(3),209-221.
MLA Shunyou Wang,et al."Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer".CANCER CELL 4.3(2003):209-221.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Shunyou Wang]'s Articles
[Jing Gao]'s Articles
[Qunying Lei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Shunyou Wang]'s Articles
[Jing Gao]'s Articles
[Qunying Lei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Shunyou Wang]'s Articles
[Jing Gao]'s Articles
[Qunying Lei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.