UM  > 中華醫藥研究院
Zebrafish models of cardiovascular diseases and their applications in herbal medicine research
Sai-Wang Seto1; Hosen Kiat2,3,4; Simon M.Y. Lee5; Alan Bensoussan1; Yu-Ting Sun1; Maggie P.M. Hoi5; Dennis Chang1
2015-10
Source PublicationEuropean journal of pharmacology
ISSN0014-2999
Volume768Pages:77-86
Abstract

The zebrafish (Danio rerio) has recently become a powerful animal model for cardiovascular research and drug discovery due to its ease of maintenance, genetic manipulability and ability for high-throughput screening. Recent advances in imaging techniques and generation of transgenic zebrafish have greatly facilitated in vivo analysis of cellular events of cardiovascular development and pathogenesis. More importantly, recent studies have demonstrated the functional similarity of drug metabolism systems between zebrafish and humans, highlighting the clinical relevance of employing zebrafish in identifying lead compounds in Chinese herbal medicine with potential beneficial cardiovascular effects. This paper seeks to summarise the scope of zebrafish models employed in cardiovascular studies and the application of these research models in Chinese herbal medicine to date. Crown Copyright (C) 2015 Published by Elsevier B.V. All rights reserved.

KeywordZebrafish Chinese Herbal Medicine Cardiovascular Animal Model Review
DOIhttp://www.doi.org/10.1016/j.ejphar.2015.10.031
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000364842800009
Fulltext Access
Citation statistics
Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDennis Chang
Affiliation1.National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW, Australia
2.Faculty of Medicine, University of New South Wales, NSW, Australia
3.School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, NSW, Australia
4.Faculty of Medicine and Health Sciences, Macquarie University, NSW, Australia
5.State Key Laboratory Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation
GB/T 7714
Sai-Wang Seto,Hosen Kiat,Simon M.Y. Lee,et al. Zebrafish models of cardiovascular diseases and their applications in herbal medicine research[J]. European journal of pharmacology,2015,768:77-86.
APA Sai-Wang Seto.,Hosen Kiat.,Simon M.Y. Lee.,Alan Bensoussan.,Yu-Ting Sun.,...&Dennis Chang.(2015).Zebrafish models of cardiovascular diseases and their applications in herbal medicine research.European journal of pharmacology,768,77-86.
MLA Sai-Wang Seto,et al."Zebrafish models of cardiovascular diseases and their applications in herbal medicine research".European journal of pharmacology 768(2015):77-86.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sai-Wang Seto]'s Articles
[Hosen Kiat]'s Articles
[Simon M.Y. Lee]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sai-Wang Seto]'s Articles
[Hosen Kiat]'s Articles
[Simon M.Y. Lee]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sai-Wang Seto]'s Articles
[Hosen Kiat]'s Articles
[Simon M.Y. Lee]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.