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Effect of rs1344706 in the ZNF804A gene on the brain network
Chen, Xiongying1; Zhang, Zhifang1; Zhang, Qiumei1,2; Zhao, Wan1; Zhai, Jinguo2; Chen, Min2; Du, Boqi1; Deng, Xiaoxiang1; Ji, Feng2; Wang, Chuanyue3; Xiang, Yu-Tao3,4; Wu, Hongjie5; Dong, Qi1; Chen, Chuansheng6; Li, Jun1

ZNF804A rs1344706 (A/C) was the first SNP that reached genome-wide significance for schizophrenia. Recent studies have linked rs1344706 to functional connectivity among specific brain regions. However, no study thus far has examined the role of this SNP in the entire functional connectome. In this study, we used degree centrality to test the role of rs1344706 in the whole-brain voxel-wise functional connectome during the resting state. 52 schizophrenia patients and 128 healthy controls were included in the final analysis. In our whole-brain analysis, we found a significant interaction effect of genotype x diagnosis at the precuneus (PCU) (cluster size = 52 voxels, peak voxel MNI coordinates: x = 9, y = -69, z = 63, F = 32.57, FWE corrected P < 0.001). When we subdivided the degree centrality network according to anatomical distance, the whole-brain analysis also found a significant interaction effect of genotype xdiagnosis at the PCU with the same peak in the short-range degree centrality network (cluster size = 72 voxels, F = 37.29, FWE corrected P < 0.001). No significant result was found in the long-range degree centrality network. Our results elucidated the contribution of rs1344706 to functional connectivity within the brain network, and may have important implications for our understanding of this risk gene's role in functional dysconnectivity in schizophrenia.

KeywordZnf804a Schizophrenia Functional Magnetic Resonance Imaging Degree Centrality Brain Network Pcc/pcu
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Indexed BySCI
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000426180300103
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLi, Jun
Affiliation1.State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, PR China
2.School of Mental Health, Jining Medical University, 45# Jianshe South Road, Jining 272013, Shandong Province, PR China
3.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing 100088, PR China
4.Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, PR China
5.Shengli Hospital of Shengli Petroleum Administration Bureau, Dongying 257022, Shandong Province, PR China
6.Department of Psychology and Social Behavior, University of California, Irvine, CA 92697, United States
Recommended Citation
GB/T 7714
Chen, Xiongying,Zhang, Zhifang,Zhang, Qiumei,et al. Effect of rs1344706 in the ZNF804A gene on the brain network[J]. NEUROIMAGE-CLINICAL,2018,17:1000-1005.
APA Chen, Xiongying.,Zhang, Zhifang.,Zhang, Qiumei.,Zhao, Wan.,Zhai, Jinguo.,...&Li, Jun.(2018).Effect of rs1344706 in the ZNF804A gene on the brain network.NEUROIMAGE-CLINICAL,17,1000-1005.
MLA Chen, Xiongying,et al."Effect of rs1344706 in the ZNF804A gene on the brain network".NEUROIMAGE-CLINICAL 17(2018):1000-1005.
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