At present, mesenchymal stem cells (MSCs) are regarded as a candidate for neovascularization and tissue regeneration after ischemic stroke. Numerous studies reported that Angelica (also called Dong quai, a well-known Chinese herbal medicine) extracts and its active ingredients such as ligustilide, n-Butylphthalide and sodium ferulate had significant effects of anti-inflammatory, anti-activation of oxygen free radicals, angiogenesis, anti-platelet aggregation, neuroprotection and so on. Angelica’ active compositions facilitated MSCs to migrate into infarcted zone and differentiation. Moreover, MSCs combined with angelica’ active components improved neurological function and decreased infarcted volume, advanced neovascularization and neurogenesis, regulated astrocytes characteristics, enhanced regional cerebral blood flow and glucose metabolism, as well as reduced brain-blood barrier permeability in infarction. Consequently, the structure and function of neurovascular unit in infarct region partly obtained recovery. Therefore, the combination treatment was a valuable therapy aimed at improving post-stroke restoration.