Combination Treatment of Mesenchymal Stem Cells (MSCs) and Angelica sinensis’ Active Ingredients for Ischemic Stroke | |
Zhang, Qian; Zhao, Yonghua![]() | |
2017 | |
Source Publication | Cellular and Molecular Approaches to Regeneration and Repair |
Author of Source | Paul A. Lapchak, John H. Zhang |
Publisher | Springer |
Pages | 239-257 |
Abstract | At present, mesenchymal stem cells (MSCs) are regarded as a candidate for neovascularization and tissue regeneration after ischemic stroke. Numerous studies reported that Angelica (also called Dong quai, a well-known Chinese herbal medicine) extracts and its active ingredients such as ligustilide, n-Butylphthalide and sodium ferulate had significant effects of anti-inflammatory, anti-activation of oxygen free radicals, angiogenesis, anti-platelet aggregation, neuroprotection and so on. Angelica’ active compositions facilitated MSCs to migrate into infarcted zone and differentiation. Moreover, MSCs combined with angelica’ active components improved neurological function and decreased infarcted volume, advanced neovascularization and neurogenesis, regulated astrocytes characteristics, enhanced regional cerebral blood flow and glucose metabolism, as well as reduced brain-blood barrier permeability in infarction. Consequently, the structure and function of neurovascular unit in infarct region partly obtained recovery. Therefore, the combination treatment was a valuable therapy aimed at improving post-stroke restoration. |
Keyword | Angelica Sinensis Combination Treatment Ischemic Stroke Mesenchymal Stem Cells |
DOI | http://dx.doi.org/10.1007/978-3-319-66679-2_12 |
Language | 英语 |
ISBN | 978-3-319-66678-5 |
Fulltext Access | |
Citation statistics | |
Document Type | Book chapter |
Collection | Institute of Chinese Medical Sciences |
Affiliation | State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese MedicineMacau University of Science and TechnologyMacauChina |
Recommended Citation GB/T 7714 | Zhang, Qian,Zhao, Yonghua. Combination Treatment of Mesenchymal Stem Cells (MSCs) and Angelica sinensis’ Active Ingredients for Ischemic Stroke:Springer,2017:239-257. |
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