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Combination Treatment of Mesenchymal Stem Cells (MSCs) and Angelica sinensis’ Active Ingredients for Ischemic Stroke
Zhang, Qian; Zhao, Yonghua
Source PublicationCellular and Molecular Approaches to Regeneration and Repair
Author of SourcePaul A. Lapchak, John H. Zhang

At present, mesenchymal stem cells (MSCs) are regarded as a candidate for neovascularization and tissue regeneration after ischemic stroke. Numerous studies reported that Angelica (also called Dong quai, a well-known Chinese herbal medicine) extracts and its active ingredients such as ligustilide, n-Butylphthalide and sodium ferulate had significant effects of anti-inflammatory, anti-activation of oxygen free radicals, angiogenesis, anti-platelet aggregation, neuroprotection and so on. Angelica’ active compositions facilitated MSCs to migrate into infarcted zone and differentiation. Moreover, MSCs combined with angelica’ active components improved neurological function and decreased infarcted volume, advanced neovascularization and neurogenesis, regulated astrocytes characteristics, enhanced regional cerebral blood flow and glucose metabolism, as well as reduced brain-blood barrier permeability in infarction. Consequently, the structure and function of neurovascular unit in infarct region partly obtained recovery. Therefore, the combination treatment was a valuable therapy aimed at improving post-stroke restoration.

KeywordAngelica Sinensis Combination Treatment Ischemic Stroke Mesenchymal Stem Cells
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Document TypeBook chapter
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese MedicineMacau University of Science and TechnologyMacauChina
Recommended Citation
GB/T 7714
Zhang, Qian,Zhao, Yonghua. Combination Treatment of Mesenchymal Stem Cells (MSCs) and Angelica sinensis’ Active Ingredients for Ischemic Stroke:Springer,2017:239-257.
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