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抗肿瘤中药新型药物传递系统的研究(二)——活血化瘀类中药
申东艳; 陈美婉; 王胜鹏; 李鹏; 王一涛
2013-05-31
Source Publication世界科学技术-中医药现代化
ISSN1674-3849
Volume15Issue:1
Abstract

活血化瘀类抗肿瘤中药如莪术、姜黄和延胡索等通过改善血液高凝状态和恶性肿瘤的内环境,发挥其抗肿瘤作用,尤其在抗肿瘤转移方面具有优势,但其有效成分(挥发油等)多存在稳定性差、吸收困难和生物利用度低等缺陷,严重影响了该类中药的临床治疗效果。在中医药理论的指导下,新型药物传递系统已使活血化瘀类抗肿瘤中药得到广泛的研究和开发,进一步拓展了活血化瘀类抗肿瘤中药的临床使用。本文针对活血化瘀类抗肿瘤中药的新型药物传递系统,以及对常用的莪术、姜黄、虎杖等3 种活血化瘀类抗肿瘤中药的新型制剂进行综述,旨在为该类抗肿瘤中药新剂型的研发提供理论和现实参考。

Other Abstract

   Blood-activating and stasis-resolving Chinese medicine, such as Rhizoma Curcumae, Rhizoma Curcumae Longae and Rhizoma Corydalis, can work as anti-tumor medicines especially in the area of anti-metastatic by changing the blood hypercoagulable state and improving internal environment of tumors. However, lots of active ingredients from this kind of medicine including volatile oil have the disadvantage of poor stability and absorption, and low bioavailability which have weakened the clinical application. In recent years, under the guidance of Chinese medicine theory and advanced technology of modern pharmaceutics based on new pharmaceutical excipients and preparation process, novel drug delivery systems, for example, liposome, microsphere, microcapsule, nanoparticle, and solid dispersion, have already been used in the research and development of this kind of Chinese medicines. This paper reviewed the novel drug delivery systems of blood-activating and stasis-resolving Chinese medicine and focused on Rhizoma Curcumae, Rhizoma Curcumae Longae, and Rhizoma Polygoni Cuspidati. We hope to provide theoretical and practical reference for the research and development of new formulations in antitumor Chinese medicine.

Keyword抗肿瘤中药 新型药物传递系统 活血化瘀药
DOIhttps://doi.org/10.3969/j.issn.1674-3849.2013.01.007
Language中文
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation澳门大学中药质量研究国家重点实验室/澳门大学中华医药研究院 澳门 999078
Recommended Citation
GB/T 7714
申东艳,陈美婉,王胜鹏,等. 抗肿瘤中药新型药物传递系统的研究(二)——活血化瘀类中药[J]. 世界科学技术-中医药现代化,2013,15(1).
APA 申东艳,陈美婉,王胜鹏,李鹏,&王一涛.(2013).抗肿瘤中药新型药物传递系统的研究(二)——活血化瘀类中药.世界科学技术-中医药现代化,15(1).
MLA 申东艳,et al."抗肿瘤中药新型药物传递系统的研究(二)——活血化瘀类中药".世界科学技术-中医药现代化 15.1(2013).
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