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Highly Water‐Dispersible Surface‐Modified Gd2O3 Nanoparticles for Potential Dual‐Modal Bioimaging
Hu, ZJ1; Ahren, M1; Selegard, L1; Skoglund, C1; Soderlind, F2; Engstrom, M3; Zhang, XJ1; Uvdal, K1
2013
Source PublicationCHEMISTRY-A EUROPEAN JOURNAL
ISSN0947-6539
Volume19Issue:38Pages:12658-12667
Abstract

Water-dispersible and luminescent gadolinium oxide (GO) nanoparticles (NPs) were designed and synthesized for potential dual-modal biological imaging. They were obtained by capping gadolinium oxide nanoparticles with a fluorescent glycol-based conjugated carboxylate (HL). The obtained nanoparticles(GO-L) show long-term colloidal stability and intense blue fluorescence. In addition, L can sensitize the luminescence of europium(III) through the so-called antenna effect. Thus, to extend the spectral ranges of emission, europium was introduced into L-modified gadolinium oxide nanoparticles. The obtained Eu-III-doped particles (Eu:GO-L) can provide visible red emission, which is more intensive than that without L capping. The average diameter of the monodisperse modified oxide cores is about 4nm. The average hydrodynamic diameter of the L-modified nanoparticles was estimated to be about 13nm. The nanoparticles show effective longitudinal water proton relaxivity. The relaxivity values obtained for GO-L and Eu:GO-L were r(1)=6.4 and 6.3s(-1)mM(-1) with r(2)/r(1) ratios close to unity at 1.4T. Longitudinal proton relaxivities of these nanoparticles are higher than those of positive contrast agents based on gadolinium complexes such as Gd-DOTA, which are commonly used for clinical magnetic resonance imaging. Moreover, these particles are suitable forcellular imaging and show good biocompatibility.

KeywordGadolinium Oxide Imaging Agents Luminescence Magnetic Resonance Imaging Nanoparticles
DOIhttps://doi.org/10.1002/chem.201301687
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000324316300018
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Cited Times [WOS]:25   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Linkoping Univ, Dept Phys Chem & Biol IFM, Div Mol Surface Phys & Nanosci, S-58183 Linkoping, Sweden
2.Linkoping Univ, Dept Phys Chem & Biol IFM, Div Nanostruct Mat, S-58183 Linkoping, Sweden
3.Linkoping Univ, Ctr Med Image Sci & Visualizat CMIV, S-58185 Linkoping, Sweden
Recommended Citation
GB/T 7714
Hu, ZJ,Ahren, M,Selegard, L,et al. Highly Water‐Dispersible Surface‐Modified Gd2O3 Nanoparticles for Potential Dual‐Modal Bioimaging[J]. CHEMISTRY-A EUROPEAN JOURNAL,2013,19(38):12658-12667.
APA Hu, ZJ.,Ahren, M.,Selegard, L.,Skoglund, C.,Soderlind, F.,...&Uvdal, K.(2013).Highly Water‐Dispersible Surface‐Modified Gd2O3 Nanoparticles for Potential Dual‐Modal Bioimaging.CHEMISTRY-A EUROPEAN JOURNAL,19(38),12658-12667.
MLA Hu, ZJ,et al."Highly Water‐Dispersible Surface‐Modified Gd2O3 Nanoparticles for Potential Dual‐Modal Bioimaging".CHEMISTRY-A EUROPEAN JOURNAL 19.38(2013):12658-12667.
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