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One-step synthesis of water-dispersible ultra-small Fe3O4 nanoparticles as contrast agents for T1 and T2 magnetic resonance imaging
Wang, GN1,3; Zhang, XJ3; Skallberg, A3; Liu, YX1,2; Hu, ZJ3; Mei, XF2; Uvdal, K3
2014
Source PublicationNANOSCALE
ISSN2040-3364
Volume6Issue:5Pages:2953-2963
Abstract

Uniform, highly water-dispersible and ultra-small Fe3O4 nanoparticles were synthesized via a modified one-step coprecipitation approach. The prepared Fe3O4 nanoparticles not only show good magnetic properties, long-term stability in a biological environment, but also exhibit good biocompatibility in cell viability and hemolysis assay. Due to the ultra-small sized and highly water-dispersibility, they exhibit excellent relaxivity properties, the 1.7 nm sized Fe3O4 nanoparticles reveal a low r(2)/r(1) ratio of 2.03 (r(1) = 8.20 mM(-1) s(-1), r(2) = 16.67 mM(-1) s(-1)); and the 2.2 nm sized Fe3O4 nanoparticles also appear to have a low r2/r1 ratio of 4.65 (r(1) = 6.15 mM(-1) s(-1), r(2) = 28.62 mM(-1) s(-1)). This demonstrates that the proposed ultra-small Fe3O4 nanoparticles have great potential as a new type of T-1 magnetic resonance imaging contrast agents. Especially, the 2.2 nm sized Fe3O4 nanoparticles, have a competitive r(1) value and r(2) value compared to commercial contrasting agents such as Gd-DTPA (r(1) = 4.8 mM(-1) s(-1)), and SHU-555C (r(2) = 69 mM(-1) s(-1)). In vitro and in vivo imaging experiments, show that the 2.2 nm sized Fe3O4 nanoparticles exhibit great contrast enhancement, long-term circulation, and low toxicity, which enable these ultrasmall sized Fe3O4 nanoparticles to be promising as T-1 and T-2 dual contrast agents in clinical settings.

DOIhttp://dx.doi.org/10.1039/c3nr05550g
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000332127200059
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Cited Times [WOS]:71   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Liaoning Med Univ, Coll Pharm, Dept Chem, Jinzhou 121001, Peoples R China
2.Liaoning Med Univ, Key Lab Med Tissue Engn Liaoning Prov, Jinzhou 121001, Peoples R China
3.Linkoping Univ, Dept Phys Chem & Biol, Div Mol Surface Phys & Nanosci, S-58183 Linkoping, Sweden
Recommended Citation
GB/T 7714
Wang, GN,Zhang, XJ,Skallberg, A,et al. One-step synthesis of water-dispersible ultra-small Fe3O4 nanoparticles as contrast agents for T1 and T2 magnetic resonance imaging[J]. NANOSCALE,2014,6(5):2953-2963.
APA Wang, GN.,Zhang, XJ.,Skallberg, A.,Liu, YX.,Hu, ZJ.,...&Uvdal, K.(2014).One-step synthesis of water-dispersible ultra-small Fe3O4 nanoparticles as contrast agents for T1 and T2 magnetic resonance imaging.NANOSCALE,6(5),2953-2963.
MLA Wang, GN,et al."One-step synthesis of water-dispersible ultra-small Fe3O4 nanoparticles as contrast agents for T1 and T2 magnetic resonance imaging".NANOSCALE 6.5(2014):2953-2963.
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