UM
Surfactant-Free Interface Suspended Gold Graphitic Surface-Enhanced Raman Spectroscopy Substrate for Simultaneous Multiphase Analysis
Zhang, Liang; Liu, Fang; Zou, Yuxiu; Hu, Xiaoxiao; Huang, Siqi; Xu, Yiting; Zhang, Lufeng; Dong, Qian; Liu, Zhangkun; Chen, Long; Chen, Zhuo; Tan, Weihong
2018-10-02
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume90Issue:19Pages:11183-11187
AbstractSimultaneous multiphase detection of multiplex analytes is important, albeit challenging, especially in pharmaceuticals analysis since drugs with lipid and water solubility were often administrated together for synergistic therapy. Surface-enhanced Raman spectroscopy (SERS) is a label-free and sensitive tool for multiplex analytes detection at multiphase interfaces. However, the requirements of inducers or surfactant surface modification of the SERS substrate have restricted extensive applications. Herein, we developed a graphene-isolated-Au-nanocrystal based multiphase analysis system. Unexpectedly, the gold graphitic SERS substrate can simply suspend at the interface of the different phase without the involvement of any surfactant. Therefore, the proximity of substrate with analyte molecules remains unaffected. Such suspended substrate not only ensures sensitive SERS detection but also enables the enrichment of analytes from the different phase simultaneously without interference. Moreover, the graphitic shell of the SERS substrate has a unique vibration band located in the Raman biological silence region which is utilized as the internal standard and improves the SERS quantification accuracy. Efficient ex vivo multiphase enrichment and detection of mimic lipidand water-soluble drugs injected into mice were demonstrated with such gold graphitic substrate, showing the potential of this simultaneous multiplex pharmacokinetic analysis.
DOI10.1021/acs.analchem.8b03040
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000446542600004
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Recommended Citation
GB/T 7714
Zhang, Liang,Liu, Fang,Zou, Yuxiu,et al. Surfactant-Free Interface Suspended Gold Graphitic Surface-Enhanced Raman Spectroscopy Substrate for Simultaneous Multiphase Analysis[J]. ANALYTICAL CHEMISTRY,2018,90(19):11183-11187.
APA Zhang, Liang.,Liu, Fang.,Zou, Yuxiu.,Hu, Xiaoxiao.,Huang, Siqi.,...&Tan, Weihong.(2018).Surfactant-Free Interface Suspended Gold Graphitic Surface-Enhanced Raman Spectroscopy Substrate for Simultaneous Multiphase Analysis.ANALYTICAL CHEMISTRY,90(19),11183-11187.
MLA Zhang, Liang,et al."Surfactant-Free Interface Suspended Gold Graphitic Surface-Enhanced Raman Spectroscopy Substrate for Simultaneous Multiphase Analysis".ANALYTICAL CHEMISTRY 90.19(2018):11183-11187.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Liang]'s Articles
[Liu, Fang]'s Articles
[Zou, Yuxiu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Liang]'s Articles
[Liu, Fang]'s Articles
[Zou, Yuxiu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Liang]'s Articles
[Liu, Fang]'s Articles
[Zou, Yuxiu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.