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Magneto-fluorescent nanoparticles with high-intensity NIR emission, T1- and T2-weighted MR for multimodal specific tumor imaging
Wang, GN1,2,3; Zhang, XJ4; Liu, YX1,2; Hu, ZJ3; Mei, XF1,2; Uvdal, K3
2015
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-7518
Volume3Issue:15Pages:3072-3080
Abstract

Nanoparticles exhibiting bright near-infrared (NIR) fluorescence, T-1-and T-2-weighted MR were synthesized for specific tumor imaging. Clinically used Fe3O4 nanoparticles exhibit an intrinsic dark signal (T-2-weighted MRI), which sometimes misleads clinical diagnosis. Here, for the first time we integrated ultrasmall Fe3O4 nanoparticles (2-3 nm) with an NIR emitting semiconducting polymer for both T-1-and T-2-weighted MRI as well as fluorescence imaging of tumors. Bio-functionalized multi-modality fluorescent magnetic nanoparticles (FMNPs) functionalized with folic acid exhibit bright fluorescence and highrelaxation (r(1) = 7.008 mM(-1) s(-1), r(2) = 26.788 mM(-1) s(-1), r(2)/r(1) = 3.8). These FMNPs have a small average dynamic size of about 20 nm with low aggregation and long circulation time. In vitro studies revealed that FMNPs can serve as an effective fluorescent probe to achieve targeting images of human A549 lung cancer cells without obvious cytotoxicity. In vivo experimental results show that the FMNPs are able to preferentially accumulate in tumor tissues for specific fluorescence imaging, T-1-and T-2-weighted MRI.

DOIhttp://dx.doi.org/10.1039/c5tb00155b
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000352287400018
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Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Liaoning Med Univ, Coll Pharm, Jinzhou 121001, Peoples R China
2.Liaoning Med Univ, Key Lab Med Tissue Engn Liaoning Prov, Jinzhou 121001, Peoples R China
3.Linkoping Univ, Dept Phys Chem & Biol, Div Mol Surface Phys & Nanosci, S-58183 Linkoping, Sweden
4.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
Recommended Citation
GB/T 7714
Wang, GN,Zhang, XJ,Liu, YX,et al. Magneto-fluorescent nanoparticles with high-intensity NIR emission, T1- and T2-weighted MR for multimodal specific tumor imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(15):3072-3080.
APA Wang, GN,Zhang, XJ,Liu, YX,Hu, ZJ,Mei, XF,&Uvdal, K.(2015).Magneto-fluorescent nanoparticles with high-intensity NIR emission, T1- and T2-weighted MR for multimodal specific tumor imaging.JOURNAL OF MATERIALS CHEMISTRY B,3(15),3072-3080.
MLA Wang, GN,et al."Magneto-fluorescent nanoparticles with high-intensity NIR emission, T1- and T2-weighted MR for multimodal specific tumor imaging".JOURNAL OF MATERIALS CHEMISTRY B 3.15(2015):3072-3080.
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