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Au Nanocage Functionalized with Ultra-small Fe3O4 Nanoparticles for Targeting T1–T2Dual MRI and CT Imaging of Tumor
Wang, GN1,2,3; Gao, W1,2; Zhang, XJ3; Mei, XF1,2
2016
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6
Abstract

Diagnostic approaches based on multimodal imaging of clinical noninvasive imaging (eg. MRI/CT scanner) are highly developed in recent years for accurate selection of the therapeutic regimens in critical diseases. Therefore, it is highly demanded in the development of appropriate all-in-one multimodal contrast agents (MCAs) for the MRI/CT multimodal imaging. Here a novel ideal MCAs (F-AuNC@Fe3O4) were engineered by assemble Au nanocages (Au NC) and ultra-small iron oxide nanoparticles (Fe3O4) for simultaneous T-1-T-2 dual MRI and CT contrast imaging. In this system, the Au nanocages offer facile thiol modification and strong X-ray attenuation property for CT imaging. The ultra-small Fe3O4 nanoparticles, as excellent contrast agent, is able to provide great enhanced signal of T-1- and T-2-weighted MRI (r(1) = 6.263 mM(-1) s(-1), r(2) = 28.117 mM(-1) s(-1)) due to their ultra-refined size. After functionalization, the present MCAs nanoparticles exhibited small average size, low aggregation and excellent biocompatible. In vitro and In vivo studies revealed that the MCAs show long-term circulation time, renal clearance properties and outstanding capability of selective accumulation in tumor tissues for simultaneous CT imaging and T-1- and T-2-weighted MRI. Taken together, these results show that as-prepared MCAs are excellent candidates as MRI/CT multimodal imaging contrast agents.

DOIhttp://dx.doi.org/10.1038/srep28258
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000377997900001
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Cited Times [WOS]:33   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Faculty of Health Sciences
Affiliation1.Liaoning Med Univ, Coll Pharm, Jinzhou 121001, Peoples R China
2.Univ Macau, Fac Hlth Sci, Ave Univ, Taipa, Macau, Peoples R China
3.Liaoning Med Univ, Key Lab Med Tissue Engn Liaoning Prov, Jinzhou 121001, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wang, GN,Gao, W,Zhang, XJ,et al. Au Nanocage Functionalized with Ultra-small Fe3O4 Nanoparticles for Targeting T1–T2Dual MRI and CT Imaging of Tumor[J]. SCIENTIFIC REPORTS,2016,6.
APA Wang, GN,Gao, W,Zhang, XJ,&Mei, XF.(2016).Au Nanocage Functionalized with Ultra-small Fe3O4 Nanoparticles for Targeting T1–T2Dual MRI and CT Imaging of Tumor.SCIENTIFIC REPORTS,6.
MLA Wang, GN,et al."Au Nanocage Functionalized with Ultra-small Fe3O4 Nanoparticles for Targeting T1–T2Dual MRI and CT Imaging of Tumor".SCIENTIFIC REPORTS 6(2016).
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