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Systematic Review of the Efficacy and Safety of Herbal Medicines for Alzheimer’s Disease
Man, Sui Cheung1; Durairajan, Siva Sundara Kumar1; Kum, Wan Fung1; Lu, Jia Hong1; Huang, Jian Dong2; Cheng, Ching Fung1; Chung, Vincent3; Xu, Min1; Li, Min1
2008
Source PublicationJournal of Alzheimer's Disease
ISSN1387-2877
Volume14Issue:2Pages:209-223
Abstract

A systematic review was conducted to assess the efficacy and safety of herbal medications ( HM), as either monotherapy or adjunct to orthodox medications ( cholinesterase inhibitors and nootropic agents, OM) for Alzheimer's disease ( AD). Sixteen studies testing different HM were included. Out of the 15 HM monotherapy studies, 13 reported HM to be significantly better than OM or placebo; one reported similar efficacy between HM and OM. Only the HM adjuvant study reported significant efficacy. No major adverse events for HM were reported and HMs were found to reduce the adverse effects arising from OM. Imbalance in ethnicity among participants was observed; gender distribution was unclear. Heterogeneity in diagnostic criteria, interventions and outcome measures hindered comprehensive data analysis. Studies comparing HM with OM suggest that HM can be a safe, effective treatment for AD, either alone or in conjunction with OM. Methodological flaws in the design of the studies, however, limited the extent to which the results could be interpreted. Among various HMs, the safety and tolerability of EGb761 was best established. Further multi-center trials with large sample size, high methodological qualities and standardized HM ingredients are necessary for clinical recommendations on the use of HM in treating AD.

KeywordAlzheimer's Disease Clinical Trial Herbal Medicine Systematic Review
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000256624400009
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLi, Min
Affiliation1.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China
2.Univ Hong Kong, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Sch Publ Hlth, Shatin, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Man, Sui Cheung,Durairajan, Siva Sundara Kumar,Kum, Wan Fung,et al. Systematic Review of the Efficacy and Safety of Herbal Medicines for Alzheimer’s Disease[J]. Journal of Alzheimer's Disease,2008,14(2):209-223.
APA Man, Sui Cheung.,Durairajan, Siva Sundara Kumar.,Kum, Wan Fung.,Lu, Jia Hong.,Huang, Jian Dong.,...&Li, Min.(2008).Systematic Review of the Efficacy and Safety of Herbal Medicines for Alzheimer’s Disease.Journal of Alzheimer's Disease,14(2),209-223.
MLA Man, Sui Cheung,et al."Systematic Review of the Efficacy and Safety of Herbal Medicines for Alzheimer’s Disease".Journal of Alzheimer's Disease 14.2(2008):209-223.
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